دورية أكاديمية
Dual biomarkers-activatable hollow MnO 2 -Based theranostic nanoplatform for efficient breast cancer-specific multisite fluorescence imaging and synergistic therapy.
| العنوان: | Dual biomarkers-activatable hollow MnO |
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| المؤلفون: | Ning J; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China., Hu G; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China., Wu T; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China., Zhao Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China., Nie Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China. Electronic address: ymnie@henu.edu.cn., Zhou Y; Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemical and Molecular Sciences, Henan University, Kaifeng, 475004, China. Electronic address: zhouyanmei@henu.edu.cn. |
| المصدر: | Analytica chimica acta [Anal Chim Acta] 2024 May 15; Vol. 1303, pp. 342521. Date of Electronic Publication: 2024 Mar 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam. |
| مواضيع طبية MeSH: | DNA, Catalytic* , Neoplasms* , Carbocyanines*, Precision Medicine ; Manganese Compounds ; Oxides ; Optical Imaging ; Biomarkers |
| مستخلص: | Background: Theranostic nanoplatforms with integrated diagnostic imaging and multiple therapeutic functions play a vital role in precise diagnosis and efficient treatment for breast cancer, but unfortunately, these nanoplatforms are usually stuck in single-site imaging and single mode of treatment, causing unsatisfactory diagnostic and therapeutic efficiency. Herein, a dual biomarkers-activatable facile hollow mesoporous MnO Results: The DHMM acted as an integrated diagnostic and therapeutic nanoplatform that realizes multi-site fluorescence imaging-guided high-efficient photothermal/chemodynamic/gene synergistic therapy (PTT/CDT/GT) for breast cancer. The H-MnO Significance: This dual biomarker-activatable multiple therapeutic nanoplatform was realized multi-site fluorescence imaging-guided PTT/CDT/GT combination therapy for breast cancer with higher specificity and efficiency, which provides a promising theranostic nanoplatform for the precision and efficiency of breast cancer treatment. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; Hollow mesoporous MnO(2); Multi-site Fluorescence imaging; Synergistic therapy; Theranostic nanoplatform |
| المشرفين على المادة: | 0 (cyanine dye 5) 0 (DNA, Catalytic) 0 (Manganese Compounds) 0 (Oxides) 0 (Biomarkers) 0 (Carbocyanines) |
| تواريخ الأحداث: | Date Created: 20240412 Date Completed: 20240415 Latest Revision: 20240509 |
| رمز التحديث: | 20240510 |
| DOI: | 10.1016/j.aca.2024.342521 |
| PMID: | 38609263 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4324 |
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| DOI: | 10.1016/j.aca.2024.342521 |