دورية أكاديمية
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.
| العنوان: | Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis. |
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| المؤلفون: | Alvarez-Martinez M; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Cox LS; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Pearson CF; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Branchett WJ; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Chakravarty P; Computational Biology Laboratory, The Francis Crick Institute, London, UK., Wu X; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Slawinski H; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Al-Dibouni A; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Samelis VA; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Gabryšová L; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK., Priestnall SL; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.; Experimental Histopathology, The Francis Crick Institute, London, UK., Suárez-Bonnet A; Department of Pathobiology and Population Sciences, Royal Veterinary College, London, UK.; Experimental Histopathology, The Francis Crick Institute, London, UK., Mikolajczak A; Experimental Histopathology, The Francis Crick Institute, London, UK., Briscoe J; Developmental Dynamics Laboratory, The Francis Crick Institute, London, UK., Powrie F; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., O'Garra A; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK. Anne.OGarra@crick.ac.uk.; National Heart and Lung Institute, Imperial College London, London, UK. Anne.OGarra@crick.ac.uk. |
| المصدر: | Nature immunology [Nat Immunol] 2024 May; Vol. 25 (5), pp. 886-901. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
| مواضيع طبية MeSH: | Positive Regulatory Domain I-Binding Factor 1*/genetics , Positive Regulatory Domain I-Binding Factor 1*/metabolism , Proto-Oncogene Proteins c-maf*/genetics , Colitis*/immunology , Colitis*/genetics , Mice, Knockout* , Helicobacter hepaticus*/immunology, Animals ; Mice ; Humans ; Helicobacter Infections/immunology ; Mice, Inbred C57BL ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Intestinal Mucosa/microbiology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/genetics ; Gene Expression Regulation ; Disease Models, Animal |
| مستخلص: | Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ATAC-seq of purified CD4 + T cells to show that the transcription factors Blimp-1 (encoded by Prdm1) and c-Maf co-dominantly regulate Il10 while negatively regulating proinflammatory cytokines in effector T cells. Double-deficient Prdm1 fl/fl Maf fl/fl Cd4 Cre mice infected with Helicobacter hepaticus developed severe colitis with an increase in T (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; FC001126 United Kingdom ARC_ Arthritis Research UK; FC001126 United Kingdom WT_ Wellcome Trust |
| المشرفين على المادة: | EC 2.1.1.- (Positive Regulatory Domain I-Binding Factor 1) 0 (Proto-Oncogene Proteins c-maf) 0 (Prdm1 protein, mouse) 0 (Maf protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240412 Date Completed: 20240502 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| مُعرف محوري في PubMed: | PMC11065689 |
| DOI: | 10.1038/s41590-024-01814-z |
| PMID: | 38609547 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41590-024-01814-z |