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Clinical Accuracy of Serum Neurofilament Light to Differentiate Frontotemporal Dementia from Primary Psychiatric Disorders is Age-Dependent.

التفاصيل البيبلوغرافية
العنوان: Clinical Accuracy of Serum Neurofilament Light to Differentiate Frontotemporal Dementia from Primary Psychiatric Disorders is Age-Dependent.
المؤلفون: Light V; Department of Psychiatry, McGill University (VL, SD), Douglas Mental Health University Institute, Montreal, QC, Canada; Integrated Program of Neuroscience (VL), McGill University, Montreal, QC, Canada., Jones SL; Douglas Research Centre (SLJ), Montreal, QC, Canada., Rahme E; Research Institute of the McGill University Health Centre (RI-MUHC) (ER), Montreal, QC, Canada., Rousseau K; Institut Universitaire en Santé Mentale de Montréal, Département de Psychiatrie (KR), Université de Montréal, Montreal, QC, Canada., de Boer S; Alzheimer Center Amsterdam, Department of Neurology (SB, YP), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; School of Psychology (SB), The University of Sydney, Sydney, NSW, Australia., Vermunt L; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC (LV, CT), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Soltaninejad M; McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology & Neurosurgery (MS, SD), McGill University, Montreal, QC, Canada., Teunissen C; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC (LV, CT), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology (SB, YP), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Ducharme S; Department of Psychiatry, McGill University (VL, SD), Douglas Mental Health University Institute, Montreal, QC, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology & Neurosurgery (MS, SD), McGill University, Montreal, QC, Canada. Electronic address: simon.ducharme@mcgill.ca., Consortium FS and CCNA; Centre de Recherche de l'institut universitaire en santé mentale de Montréal (SC, CCNA), Montreal, QC, Canada.
المصدر: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Aug; Vol. 32 (8), pp. 988-1001. Date of Electronic Publication: 2024 Mar 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2013- : London : Elsevier
Original Publication: Washington, DC : American Psychiatry Press
مواضيع طبية MeSH: Frontotemporal Dementia*/blood , Frontotemporal Dementia*/diagnosis , Neurofilament Proteins*/blood , Biomarkers*/blood , Mental Disorders*/blood , Mental Disorders*/diagnosis, Humans ; Middle Aged ; Female ; Male ; Aged ; Adult ; Diagnosis, Differential ; Aged, 80 and over ; Age Factors ; Case-Control Studies ; ROC Curve
مستخلص: Background: Symptoms of behavioral variant frontotemporal dementia (bvFTD) overlap with primary psychiatric disorders (PPD) making diagnosis challenging. Serum neurofilament light (sNfL) is a candidate biomarker to distinguish bvFTD from PPD, but large-scale studies in PPD are lacking.
Objective: Determine factors that influence sNfL from a large database of PPD patients, and test its diagnostic accuracy.
Design, Settings, Subjects, Measurements: Clinical data of people aged 40-81 were obtained from healthy subjects (n = 69), and patients with PPD (n = 848) or bvFTD (n = 82). sNfL was measured using Simoa technology on an HD-X instrument. Data were analyzed using general linear models, and Receiver Operating Characteristic (ROC) curve analyses to determine global and age-specific sNfL cutoffs to distinguish bvFTD from PPD, using the Youden Index.
Results: sNfL increased with age, while sex, BMI and diabetes status were modestly associated with sNfL. sNfL was slightly higher in PPD than healthy subjects (14.1 versus 11.7 pg/mL), when controlling for covariates. sNfL was markedly lower in PPD than bvFTD (14.1 versus 44.1 pg/mL). sNfL could differentiate PPD from bvFTD with an AUC = 0.868, but the effect was driven by the younger subjects between age 40-60 years at a cutoff of 16.0 pg/mL. No valid cutoff was detected over age 60, however, values of sNfL above 38.5 pg/mL, or below 13.9 pg/mL, provided 90% diagnostic certainty of bvFTD or PPD, respectively.
Conclusion: PPD have mildly elevated sNfL compared to healthy subjects but much lower than bvFTD. Results support the use of sNfL as a biomarker to differentiate PPD from bvFTD at age 60 or below, but accuracy decreases in older ages.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Behavioral variant of frontotemporal dementia (bvFTD); biomarker; dementia; diagnosis; primary psychiatric disorders (PPD); serum neurofilament light (NfL)
المشرفين على المادة: 0 (Neurofilament Proteins)
0 (neurofilament protein L)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240412 Date Completed: 20240706 Latest Revision: 20240718
رمز التحديث: 20240719
DOI: 10.1016/j.jagp.2024.03.008
PMID: 38609836
قاعدة البيانات: MEDLINE
الوصف
تدمد:1545-7214
DOI:10.1016/j.jagp.2024.03.008