دورية أكاديمية
A Study on the Biological Activity of Optically Pure Aziridine Phosphines and Phosphine Oxides.
| العنوان: | A Study on the Biological Activity of Optically Pure Aziridine Phosphines and Phosphine Oxides. |
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| المؤلفون: | Kowalczyk A; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland., Pieczonka AM; Department of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland., Kassassir H; Cellular Signalling Laboratory, Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, Poland., Rachwalski M; Department of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland., Stączek P; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2024 Mar 22; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Aziridines*/pharmacology , Phosphines*, Humans ; HeLa Cells ; Oxides |
| مستخلص: | A series of optically pure aziridine phosphines and their corresponding phosphine oxides were synthesized through established chemical methodologies. The compounds were systematically investigated for their biological properties. Notably, all synthesized compounds demonstrated moderate antibacterial activity only against the reference strain of Staphylococcus aureus . However, compounds 5 and 7 exhibited noteworthy cell viability inhibition of human cervical epithelioid carcinoma HeLa cells and endometrial adenocarcinoma Ishikawa cells. Further studies of these compounds revealed additional biological effects, including disruption of the cell membrane in high concentrations, cell cycle arrest in the S phase, and the induction of reactive oxygen species (ROS). Comparative analysis of the two classes of chiral organophosphorus derivatives of aziridines indicated that chiral phosphine oxides displayed significantly higher biological activity. Consequently, these findings suggest that chiral phosphine oxides may be potential candidates for the development of anticancer drugs. In light of the significant interest in preparations whose structure is based on a three-membered aziridine ring in terms of potential anticancer therapy, this research fits into the current research trend and should constitute a valuable addition to the current state of knowledge and the existing library of aziridine derivatives with anticancer properties. |
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| معلومات مُعتمدة: | 14/GNZPA/2022 University of Łódź |
| فهرسة مساهمة: | Keywords: aziridines; biological activity; cytotoxicity; organophosphorus compounds |
| المشرفين على المادة: | 54P5FEX9FH (aziridine) FW6947296I (phosphine) 0 (Aziridines) 0 (Oxides) 0 (Phosphines) |
| تواريخ الأحداث: | Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC11012799 |
| DOI: | 10.3390/molecules29071430 |
| PMID: | 38611710 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules29071430 |