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A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton).

التفاصيل البيبلوغرافية
العنوان: A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton).
المؤلفون: Sugitha SKJ; Department of Chemistry, Holy Cross College, Nagercoil, Affiliated to Manonmaniam Sundaranar University, Tirunelveli 627012, India., Venkatesan R; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea., Latha RG; Department of Chemistry and Research Centre, Holy Cross College, Nagercoil 629002, India., Vetcher AA; Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia n.a. P. Lumumba (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia., Al-Asbahi BA; Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia., Kim SC; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 25; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Antipyretics* , Zinc Oxide*/pharmacology , Jasminum* , Nanoparticles*, Parasympatholytics ; Acetylcholine ; Escherichia coli ; Histamine ; Nicotine ; Spectroscopy, Fourier Transform Infrared ; Staphylococcus aureus ; Anti-Inflammatory Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Plant Extracts/pharmacology
مستخلص: The green synthesis of zinc oxide nanoparticles (ZnO NPs) using plants has grown in significance in recent years. ZnO NPs were synthesized in this work via a chemical precipitation method with Jasminum sambac (JS) leaf extract serving as a capping agent. These NPs were characterized using UV-vis spectroscopy, FT-IR, XRD, SEM, TEM, TGA, and DTA. The results from UV-vis and FT-IR confirmed the band gap energies (3.37 eV and 3.50 eV) and the presence of the following functional groups: CN, OH, C=O, and NH. A spherical structure and an average grain size of 26 nm were confirmed via XRD. The size and surface morphology of the ZnO NPs were confirmed through the use of SEM analysis. According to the TEM images, the ZnO NPs had an average mean size of 26 nm and were spherical in shape. The TGA curve indicated that the weight loss starts at 100 °C, rising to 900 °C, as a result of the evaporation of water molecules. An exothermic peak was seen during the DTA analysis at 480 °C. Effective antibacterial activity was found at 7.32 ± 0.44 mm in Gram-positive bacteria ( S. aureus ) and at 15.54 ± 0.031 mm in Gram-negative ( E. coli ) bacteria against the ZnO NPs. Antispasmodic activity: the 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by (78.19%), acetylcholine (at a concentration of 1 µM) by (67.57%), and nicotine (at a concentration of 2 µg/mL) by (84.35%). The antipyretic activity was identified using the specific Shodhan vidhi method, and their anti-inflammatory properties were effectively evaluated with a denaturation test. A 0.3 mL/mL sample solution demonstrated significant reductions in stimulant effects induced by histamine (at a concentration of 1 µg/mL) by 78.19%, acetylcholine (at a concentration of 1 µM) by 67.57%, and nicotine (at a concentration of 2 µg/mL) by 84.35%. These results underscore the sample solution's potential as an effective therapeutic agent, showcasing its notable antispasmodic activity. Among the administered doses, the 150 mg/kg sample dose exhibited the most potent antipyretic effects. The anti-inflammatory activity of the synthesized NPs showed a remarkable inhibition percentage of (97.14 ± 0.005) at higher concentrations (250 µg/mL). Furthermore, a cytotoxic effect was noted when the biologically synthesized ZnO NPs were introduced to treated cells.
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معلومات مُعتمدة: 2020R1I1A3052258 National Research Foundation of Korea (NRF); RSP2024R348 King Saud University
فهرسة مساهمة: Keywords: Jasminum sambac; ZnO NPs; anti-inflammatory activity; antibacterial; antipyretic; antispasmodic; green synthesis
المشرفين على المادة: 0 (Antipyretics)
SOI2LOH54Z (Zinc Oxide)
0 (Parasympatholytics)
N9YNS0M02X (Acetylcholine)
820484N8I3 (Histamine)
6M3C89ZY6R (Nicotine)
0 (Anti-Inflammatory Agents)
0 (Anti-Bacterial Agents)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11012760
DOI: 10.3390/molecules29071464
PMID: 38611744
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29071464