دورية أكاديمية
أعرض في EDS

Isolation, Identification and Chemical Modification of Bufadienolides from Bufo melanostictus Schneider and Their Cytotoxic Activities against Prostate Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Isolation, Identification and Chemical Modification of Bufadienolides from Bufo melanostictus Schneider and Their Cytotoxic Activities against Prostate Cancer Cells.
المؤلفون: Ye Q; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.; Hainan General Hospital & Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China., Lin R; Hubei Province Key Laboratory of Traditional Chinese Medicine Resource and Chemistry, Department of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China., Chen Z; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China., Li J; Hubei Province Key Laboratory of Traditional Chinese Medicine Resource and Chemistry, Department of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China., Zheng C; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 31; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Prostatic Neoplasms*/drug therapy , Antineoplastic Agents*/pharmacology , Amphibian Venoms*/pharmacology , Bufanolides*/pharmacology, Humans ; Male ; Animals ; Bufonidae ; Lactams ; Lactones
مستخلص: The traditional Chinese medicine toad venom ( Venenum bufonis ) has been extensively used to treat various diseases, including cancers, in China and other Southeast Asian countries. The major constituents of toad venom, e.g., bufadienolides and alkaloids, exhibit broad-spectrum pharmacological effects in cancers. Herein, two new bufadienolides ( 1 and 2 ), along with eleven known compounds ( 3 - 13 ) were successfully isolated from Bufo melanostictus Schneider. Their structures were elucidated by extensive spectroscopic data and X-ray diffraction analysis. Furthermore, four lactam derivatives were synthesized through the transformation of bufadienolides lactones. The inhibitory effects of these compounds against human prostate cancer cell lines PC-3 and DU145 were evaluated. The outcomes indicated a notable trend, with a substantial subset displaying nanomolar range IC 50 values against PC-3 and DU145 cells, underscoring their pronounced cytotoxicity. Moreover, a noteworthy distinction surfaces, wherein lactones consistently outperformed their lactam counterparts, further validating their heightened potency for the treatment of prostate cancer. This study contributes significant preclinical evidence substantiating the therapeutic viability of bufadienolides and toad venom as intervention strategies for prostate cancer.
References: Nat Prod Rep. 2011 May;28(5):953-69. (PMID: 21416078)
RSC Adv. 2021 Jan 7;11(4):2158-2166. (PMID: 35424145)
Front Chem. 2023 Mar 16;11:1137547. (PMID: 37007051)
Molecules. 2021 Jul 12;26(14):. (PMID: 34299492)
Xenobiotica. 2013 May;43(5):479-85. (PMID: 23153055)
Molecules. 2020 Sep 18;25(18):. (PMID: 32961837)
Medicine (Baltimore). 2020 Jul 31;99(31):e21539. (PMID: 32756206)
Oncol Lett. 2017 Jul;14(1):15-22. (PMID: 28693129)
Front Pharmacol. 2022 Apr 05;13:797873. (PMID: 35450041)
Front Oncol. 2022 Sep 27;12:1014637. (PMID: 36237327)
Nat Prod Res. 2023 Oct-Nov;37(20):3538-3542. (PMID: 35675547)
Chem Biodivers. 2011 Apr;8(4):559-67. (PMID: 21480502)
Drug Dev Res. 2023 Aug;84(5):815-838. (PMID: 37154099)
Fitoterapia. 2019 Apr;134:362-371. (PMID: 30872126)
J Asian Nat Prod Res. 2010 Sep;12(9):793-800. (PMID: 20839128)
Methods Mol Biol. 2017;1520:85-106. (PMID: 27873247)
Nat Prod Res. 2021 Dec;35(23):4894-4900. (PMID: 32202160)
Phytochemistry. 2011 Oct;72(14-15):1779-85. (PMID: 21636103)
Arch Pharm (Weinheim). 2021 Jul;354(7):e2100060. (PMID: 33887066)
Front Pharmacol. 2023 Oct 04;14:1274336. (PMID: 37860119)
Tetrahedron Lett. 1968 Nov;(54):5669-72. (PMID: 5748699)
Molecules. 2020 Oct 01;25(19):. (PMID: 33019706)
Planta Med. 2022 Jan;88(1):43-52. (PMID: 33049786)
Bioorg Med Chem. 2022 Jul 1;65:116761. (PMID: 35504208)
J Asian Nat Prod Res. 2018 Jun;20(6):581-585. (PMID: 28625094)
J Nat Prod. 2021 May 28;84(5):1425-1433. (PMID: 33882233)
معلومات مُعتمدة: 82160735 the National Natural Science Foundation of China
فهرسة مساهمة: Keywords: bufadienolides; cytotoxic activity; toad venom
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Amphibian Venoms)
0 (Bufanolides)
0 (Lactams)
0 (Lactones)
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11013645
DOI: 10.3390/molecules29071571
PMID: 38611850
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29071571