دورية أكاديمية
Recent Advances in the Synthesis of the Marine-Derived Alkaloid Fascaplysin and Its Metabolites Homofascaplysins A-C.
| العنوان: | Recent Advances in the Synthesis of the Marine-Derived Alkaloid Fascaplysin and Its Metabolites Homofascaplysins A-C. |
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| المؤلفون: | Mittapalli RR; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA., Kumari H; James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267-0514, USA. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2024 Apr 02; Vol. 29 (7). Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Alkaloids*/pharmacology , Antineoplastic Agents* , Biological Products* , Porifera* , Quaternary Ammonium Compounds* , Carbolines* , Indoles* , Indolizines*, Animals ; Mice ; Bandages |
| مستخلص: | The fascaplysin and homofascaplysin class of marine natural products has a characteristic 12H-pyrido[1,2-a:3,4-b']diindole pentacyclic structure. Fascaplysin was isolated in 1988 from the marine sponge Fascaplysinopsis bergquist sp. The analogs of fascaplysin, such as homofascaplysins A, B, and C, were discovered late in the Fijian sponge F. reticulate, and also have potent antimicrobial activity and strong cytotoxicity against L-1210 mouse leukemia. In this review, the total synthesis of fascaplysin and its analogs, such as homofascaplysins A, B, and C, will be reviewed, which will offer useful information for medicinal chemistry researchers who are interested in the exploration of marine alkaloids. |
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| فهرسة مساهمة: | Keywords: alkaloids; fascaplysin; homofascaplysins A, B, and C; marine natural products; sponge |
| المشرفين على المادة: | 114719-57-2 (fascaplysine) 0 (Alkaloids) 0 (Antineoplastic Agents) 0 (Biological Products) 0 (Quaternary Ammonium Compounds) 0 (Carbolines) 0 (Indoles) 0 (Indolizines) |
| تواريخ الأحداث: | Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC11013045 |
| DOI: | 10.3390/molecules29071590 |
| PMID: | 38611869 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules29071590 |