دورية أكاديمية
أعرض في EDS

Epidemiological Insights into Feline Leukemia Virus Infections in an Urban Cat ( Felis catus ) Population from Brazil.

التفاصيل البيبلوغرافية
العنوان: Epidemiological Insights into Feline Leukemia Virus Infections in an Urban Cat ( Felis catus ) Population from Brazil.
المؤلفون: Diesel LP; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil., de Mello LS; Simbios Biotechnologia, Cachoeirinha 94950-000, RS, Brazil., de Oliveira Santana W; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil., Ikuta N; Simbios Biotechnologia, Cachoeirinha 94950-000, RS, Brazil., Fonseca ASK; Simbios Biotechnologia, Cachoeirinha 94950-000, RS, Brazil., Kipper D; Simbios Biotechnologia, Cachoeirinha 94950-000, RS, Brazil., Redaelli R; Gatices Veterinary Hospital, Caxias do Sul 95000-000, RS, Brazil., Pereira VRZB; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil., Streck AF; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil., Lunge VR; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul 95070-560, RS, Brazil.; Simbios Biotechnologia, Cachoeirinha 94950-000, RS, Brazil.
المصدر: Animals : an open access journal from MDPI [Animals (Basel)] 2024 Mar 29; Vol. 14 (7). Date of Electronic Publication: 2024 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
مستخلص: Feline leukemia virus (FeLV) is a retrovirus distributed worldwide in domestic cats and with different outcomes (progressive, regressive, abortive, focal). The present study reports an epidemiological survey of FeLV frequency and the evaluation of some risk factors and the two main disease outcomes (progressive and regressive) in an urban cat population from Brazil. A total of 366 cats with sociodemographic information and p27 FeLV antigen test performed were included in the study. FeLV DNA (provirus) in the blood samples of all cats was detected via real-time polymerase chain reaction (qPCR). Plasma samples from 109 FeLV-positive and FeLV-negative cats were also submitted to reverse transcription (RT-qPCR) to determine the FeLV viral load. The results demonstrated that 112 (30.6%) cats were positive through the p27 antigen and/or qPCR. A risk factor analysis demonstrated that cats without vaccination against FeLV (OR 9.9, p < 0.001), clinically ill (OR 2.9, p < 0.001), with outdoors access (OR 2.7, p < 0.001), and exhibiting apathetic behavior (OR 3.1, p < 0.001) were more likely to be infected with FeLV. FeLV-infected cats were also more likely to present with anemia (OR 13, p < 0.001) and lymphoma (OR 13.7, p = 0.001). A comparative analysis of the different detection methods in a subset of 109 animals confirmed FeLV infection in 58 cats, including 38 (65.5%) with progressive, 16 (27.6%) with regressive, and 4 (6.9%) with probably focal outcome diseases. In conclusion, this study demonstrates a high prevalence of FeLV in this urban cat population from Brazil and highlights the need to establish more effective prevention strategies (such as viral testing, vaccination programs, specific care for FeLV-positive cats) to reduce diseases associated with this virus in Brazil.
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معلومات مُعتمدة: 351573/2022-4 National Council for Scientific and Technological Development; 351240/2023-3 National Council for Scientific and Technological Development; 308445/2020-1 National Council for Scientific and Technological Development; 88887.629629/2021-00 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
فهرسة مساهمة: Keywords: Brazil; FeLV; PCR; prevalence; proviral load; viral load
تواريخ الأحداث: Date Created: 20240413 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11010845
DOI: 10.3390/ani14071051
PMID: 38612290
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2615
DOI:10.3390/ani14071051