دورية أكاديمية
أعرض في EDS

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging.

التفاصيل البيبلوغرافية
العنوان: Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging.
المؤلفون: Pereira QC; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil., Fortunato IM; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil., Oliveira FS; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil., Alvarez MC; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil.; Hematology and Transfusion Medicine Center, University of Campinas/Hemocentro, UNICAMP, Rua Carlos Chagas 480, Campinas 13083-878, SP, Brazil., Santos TWD; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil., Ribeiro ML; Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University, Av. Sao Francisco de Assis, 218, Braganca Paulista 12916-900, SP, Brazil.
المصدر: Nutrients [Nutrients] 2024 Apr 05; Vol. 16 (7). Date of Electronic Publication: 2024 Apr 05.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Gastrointestinal Microbiome* , Cardiovascular Diseases*, Aged ; Humans ; Dysbiosis ; Aging ; Communication
مستخلص: In the aging process, physiological decline occurs, posing a substantial threat to the physical and mental well-being of the elderly and contributing to the onset of age-related diseases. While traditional perspectives considered the maintenance of life as influenced by a myriad of factors, including environmental, genetic, epigenetic, and lifestyle elements such as exercise and diet, the pivotal role of symbiotic microorganisms had been understated. Presently, it is acknowledged that the intestinal microbiota plays a profound role in overall health by signaling to both the central and peripheral nervous systems, as well as other distant organs. Disruption in this bidirectional communication between bacteria and the host results in dysbiosis, fostering the development of various diseases, including neurological disorders, cardiovascular diseases, and cancer. This review aims to delve into the intricate biological mechanisms underpinning dysbiosis associated with aging and the clinical ramifications of such dysregulation. Furthermore, we aspire to explore bioactive compounds endowed with functional properties capable of modulating and restoring balance in this aging-related dysbiotic process through epigenetics alterations.
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معلومات مُعتمدة: 305402/2019-6 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: aging; dysbiosis; epigenetics; intestinal microbiota; polyphenols
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240415 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11013902
DOI: 10.3390/nu16071066
PMID: 38613099
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16071066