دورية أكاديمية
أعرض في EDS

Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness.

التفاصيل البيبلوغرافية
العنوان: Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness.
المؤلفون: van Houtum LAEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands., Baaré WFC; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark., Beckmann CF; Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, the Netherlands., Castro-Fornieles J; Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Institut Clinic de Neurociències, Hospital Clínic de Barcelona, FCRB-IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain., Cecil CAM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands., Dittrich J; Concentris Research Management Gmbh, Fürstenfeldbruck, Germany., Ebdrup BH; Center for Neuropsychiatric Schizophrenia Research and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fegert JM; President European Society for Child and Adolescent Psychiatry (ESCAP), Brussels, Belgium.; Department of Child and Adolescent Psychiatry/Psychotherapy, University Hospital Ulm, Ulm, Germany., Havdahl A; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway.; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Hillegers MHJ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands., Kalisch R; Leibniz Institute for Resilience Research, Mainz, Germany.; Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany., Kushner SA; Department of Psychiatry, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Mansuy IM; Laboratory of Neuroepigenetics, Medical Faculty, Brain Research Institute, Department of Health Science and Technology of ETH, University of Zurich and Institute for Neuroscience, Zurich, Switzerland.; Zurich Neuroscience Centre, ETH and University of Zurich, Zurich, Switzerland., Mežinska S; Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia., Moreno C; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain., Muetzel RL; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands., Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands., Nordentoft M; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Pingault JB; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Clinical, Educational and Health Psychology, University College London, London, UK., Preisig M; Psychiatric Epidemiology and Psychopathology Research Centre, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Raballo A; Public Health Division, Department of Health and Social Care, Cantonal Socio-Psychiatric Organization, Repubblica e Cantone Ticino, Mendrisio, Switzerland.; Chair of Psychiatry, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland., Saunders J; Executive Director European Federation of Associations of Families of People with Mental Illness (EUFAMI), Louvain, Belgium., Sprooten E; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands., Sugranyes G; Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Institut Clinic de Neurociències, Hospital Clínic de Barcelona, FCRB-IDIBAPS, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands.; Department of Social and Behavioural Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA., van Woerden GM; Department of Neuroscience, Erasmus University Medical Centre, Rotterdam, The Netherlands.; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Centre, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands., Vandeleur CL; Psychiatric Epidemiology and Psychopathology Research Centre, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre-Sophia, Rotterdam, The Netherlands. n.vanharen@erasmusmc.nl.
المصدر: European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2024 Apr 13. Date of Electronic Publication: 2024 Apr 13.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Country of Publication: Germany NLM ID: 9212296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-165X (Electronic) Linking ISSN: 10188827 NLM ISO Abbreviation: Eur Child Adolesc Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2010- : Heidelberg : Springer Medizin
Original Publication: Toronto ; Lewiston, NY : Hogrefe & Huber, [1992-
مستخلص: Over 50% of children with a parent with severe mental illness will develop mental illness by early adulthood. However, intergenerational transmission of risk for mental illness in one's children is insufficiently considered in clinical practice, nor is it sufficiently utilised into diagnostics and care for children of ill parents. This leads to delays in diagnosing young offspring and missed opportunities for protective actions and resilience strengthening. Prior twin, family, and adoption studies suggest that the aetiology of mental illness is governed by a complex interplay of genetic and environmental factors, potentially mediated by changes in epigenetic programming and brain development. However, how these factors ultimately materialise into mental disorders remains unclear. Here, we present the FAMILY consortium, an interdisciplinary, multimodal (e.g., (epi)genetics, neuroimaging, environment, behaviour), multilevel (e.g., individual-level, family-level), and multisite study funded by a European Union Horizon-Staying-Healthy-2021 grant. FAMILY focuses on understanding and prediction of intergenerational transmission of mental illness, using genetically informed causal inference, multimodal normative prediction, and animal modelling. Moreover, FAMILY applies methods from social sciences to map social and ethical consequences of risk prediction to prepare clinical practice for future implementation. FAMILY aims to deliver: (i) new discoveries clarifying the aetiology of mental illness and the process of resilience, thereby providing new targets for prevention and intervention studies; (ii) a risk prediction model within a normative modelling framework to predict who is at risk for developing mental illness; and (iii) insight into social and ethical issues related to risk prediction to inform clinical guidelines.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 101057529 HORIZON EUROPE Framework Programme; 22.00111, 101057529 Swiss State Secretariat for Education, Research and Innovation; 22.00170 Swiss State Secretariat for Education, Research and Innovation; 22.00170 Swiss State Secretariat for Education, Research and Innovation; 575067 UK Research and Innovation
فهرسة مساهمة: Keywords: Family; Intergenerational transmission; Mental illness; Offspring; Resilience; Risk prediction
تواريخ الأحداث: Date Created: 20240413 Latest Revision: 20240413
رمز التحديث: 20240414
DOI: 10.1007/s00787-024-02423-9
PMID: 38613677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-165X
DOI:10.1007/s00787-024-02423-9