دورية أكاديمية
أعرض في EDS

Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction.

التفاصيل البيبلوغرافية
العنوان: Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction.
المؤلفون: Liu S; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Cao Y; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Cui K; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Ren G; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zhao T; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wang X; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wei D; Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Chen Z; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Gurram RK; Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Liu C; Transgenic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wu C; Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zhu J; Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Zhao K; Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: zhaok@nhlbi.nih.gov.
المصدر: Immunity [Immunity] 2024 May 14; Vol. 57 (5), pp. 987-1004.e5. Date of Electronic Publication: 2024 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1994-
مواضيع طبية MeSH: Cell Differentiation*/immunology , Chromatin*/metabolism , Th2 Cells*/immunology , Histone Code* , Histones*/metabolism, Animals ; Mice ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation ; Mice, Inbred C57BL ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Locus Control Region ; Cytokines/metabolism
مستخلص: The development and function of the immune system are controlled by temporospatial gene expression programs, which are regulated by cis-regulatory elements, chromatin structure, and trans-acting factors. In this study, we cataloged the dynamic histone modifications and chromatin interactions at regulatory regions during T helper (Th) cell differentiation. Our data revealed that the H3K4me1 landscape established by MLL4 in naive CD4 + T cells is critical for restructuring the regulatory interaction network and orchestrating gene expression during the early phase of Th differentiation. GATA3 plays a crucial role in further configuring H3K4me1 modification and the chromatin interaction network during Th2 differentiation. Furthermore, we demonstrated that HSS3-anchored chromatin loops function to restrict the activity of the Th2 locus control region (LCR), thus coordinating the expression of Th2 cytokines. Our results provide insights into the mechanisms of how the interplay between histone modifications, chromatin looping, and trans-acting factors contributes to the differentiation of Th cells.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Published by Elsevier Inc.)
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معلومات مُعتمدة: Z01 HL005801 United States ImNIH Intramural NIH HHS; ZIA HL006030 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: GATA3; Hi-TrAC; MLL4; T helper cell differentiation; chromatin interaction; enhancer-promoter interaction; histone modification
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240515 Latest Revision: 20240517
رمز التحديث: 20240517
مُعرف محوري في PubMed: PMC11096031
DOI: 10.1016/j.immuni.2024.03.018
PMID: 38614090
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4180
DOI:10.1016/j.immuni.2024.03.018