دورية أكاديمية
Individual cytotoxicity of three major type A trichothecene, T-2, HT-2, and diacetoxyscirpenol in human Jurkat T cells.
| العنوان: | Individual cytotoxicity of three major type A trichothecene, T-2, HT-2, and diacetoxyscirpenol in human Jurkat T cells. |
|---|---|
| المؤلفون: | Wattanasuntorn P; Interdisciplinary Graduate Program in Genetic Engineering, Graduate School, Kasetsart University, Bangkok, 10900, Thailand., Phuektes P; Department of Pathobiology, Faculty of Veterinary Medicine, Khonkaen University, Khonkaen, 40002, Thailand., Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand., Mimapan S; National Institute of Animal Health (NIAH), Department of Livestock Development, Bangkok, 10900, Thailand., Tattiyapong M; National Institute of Animal Health (NIAH), Department of Livestock Development, Bangkok, 10900, Thailand., Fink-Gremmels J; Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, the Netherlands., Oswald IP; Toxalim (Research Centre in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France., Poapolathep A; Interdisciplinary Graduate Program in Genetic Engineering, Graduate School, Kasetsart University, Bangkok, 10900, Thailand; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand. Electronic address: fvetamp@hotmail.com. |
| المصدر: | Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 28; Vol. 243, pp. 107718. Date of Electronic Publication: 2024 Apr 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon Press, c1962- |
| مواضيع طبية MeSH: | Trichothecenes*/toxicity , T-2 Toxin*/toxicity , T-2 Toxin*/analogs & derivatives , Apoptosis*/drug effects , Reactive Oxygen Species*/metabolism , Cell Survival*/drug effects, Humans ; Jurkat Cells ; DNA Fragmentation/drug effects ; Cytochromes c/metabolism ; Caspase 3/metabolism ; Caspase 9/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism |
| مستخلص: | Mycotoxins are toxic, fungal secondary metabolites that contaminate agricultural commodities, food, and feed. Among them, T-2, HT-2, and diacetoxyscirpenol (DAS; the major type A trichothecene) are primarily produced from Fusarium species. These mycotoxins exert numerous toxicological effects in animals and humans, such as dermatotoxicity, haematotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, and immunotoxicity. In the present study, human Jurkat T cells were used as a model to investigate apoptotic cell death induced by T-2, HT-2, and DAS. The results showed that T-2, HT-2, and DAS decreased cell viability and increased production of Reactive Oxygen Species in a time- and dose-dependency. Based on their IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apoptosis; Cytotoxicity; Human Jurkat T cell; Trichothecene type A |
| المشرفين على المادة: | 0 (diacetoxyscirpenol) 0 (HT-2 toxin) |
| تواريخ الأحداث: | Date Created: 20240413 Date Completed: 20240517 Latest Revision: 20240517 |
| رمز التحديث: | 20240518 |
| DOI: | 10.1016/j.toxicon.2024.107718 |
| PMID: | 38614246 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3150 |
|---|---|
| DOI: | 10.1016/j.toxicon.2024.107718 |