دورية أكاديمية
أعرض في EDS

A Pilot Study for Biliary Atresia Diagnosis: Fluorescent Imaging of Indocyanine Green in Stool.

التفاصيل البيبلوغرافية
العنوان: A Pilot Study for Biliary Atresia Diagnosis: Fluorescent Imaging of Indocyanine Green in Stool.
المؤلفون: Lim YZ; Children's Research Institute at UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Mutore K; Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Bradd MV; Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA., Pandya S; Division of Pediatric Surgery, UT Southwestern Medical Center, 1935 Medical District Drive, Suite D2000, Dallas, TX 75235, USA., Corbitt N; Division of Pediatric Surgery, UT Southwestern Medical Center, 1935 Medical District Drive, Suite D2000, Dallas, TX 75235, USA. Electronic address: natasha.corbitt@utsouthwestern.edu.
المصدر: Journal of pediatric surgery [J Pediatr Surg] 2024 Jul; Vol. 59 (7), pp. 1362-1368. Date of Electronic Publication: 2024 Mar 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saunders Country of Publication: United States NLM ID: 0052631 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-5037 (Electronic) Linking ISSN: 00223468 NLM ISO Abbreviation: J Pediatr Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : Saunders
Original Publication: New York.
مواضيع طبية MeSH: Biliary Atresia*/diagnostic imaging , Biliary Atresia*/surgery , Biliary Atresia*/complications , Indocyanine Green* , Feces*/chemistry , Coloring Agents*/administration & dosage, Humans ; Pilot Projects ; Infant ; Prospective Studies ; Male ; Female ; Cholangiography/methods ; Portoenterostomy, Hepatic ; Optical Imaging/methods ; Jaundice, Obstructive/etiology ; Jaundice, Obstructive/diagnostic imaging ; Infant, Newborn
مستخلص: Background: Biliary atresia is the most common cause of obstructive jaundice in infants and conventional cholangiography is the current diagnostic gold standard. Fluorescent cholangiography with indocyanine green can enhance biliary tree visualization during surgery because it is exclusively excreted into the bile ducts and eventually into the intestine. Therefore, we hypothesized that indocyanine green presence in stool could confirm bile duct patency in infants.
Methods: A prospective single center cohort study was performed on infants (age ≤ 12 months) with and without jaundice after obtaining IRB approval. Indocyanine green was administered intravenously (0.1 mg/kg). Soiled diapers collected post-injection were imaged for fluorescence.
Results: After indocyanine green administration, fluorescence was detected in soiled diapers for control patients (n = 4, x = 14 h22 m post-injection) and jaundiced patients without biliary atresia (n = 11, x = 13 h28 m post-injection). For biliary atresia patients (n = 7), post-injection soiled diapers before and after Kasai portoenterostomy were collected. Fluorescence was not detected in stool from 6 of 7 biliary atresia patients. As a test, indocyanine green detection in stool was 97% accurate for assessing biliary patency.
Conclusion: Fluorescent Imaging for Indocyanine Green (FIInd Green) in stool is a fast and accurate approach to assess biliary patency non-invasively in infants.
Level of Evidence: Level III.
Competing Interests: Conflicts of interest The authors have no conflicts of interests to declare and no financial disclosures.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Biliary atresia; Conventional cholangiography; Fluorescent cholangiography; Indocyanine green
المشرفين على المادة: IX6J1063HV (Indocyanine Green)
0 (Coloring Agents)
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240610 Latest Revision: 20240610
رمز التحديث: 20240611
DOI: 10.1016/j.jpedsurg.2024.03.039
PMID: 38614948
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-5037
DOI:10.1016/j.jpedsurg.2024.03.039