دورية أكاديمية
Dysgeusia increases the risk for death and other side effects during antineoplastic systemic treatment for solid tumors: a cross-sectional study.
| العنوان: | Dysgeusia increases the risk for death and other side effects during antineoplastic systemic treatment for solid tumors: a cross-sectional study. |
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| المؤلفون: | Silva PG; Ceará Cancer Institute Laboratory of Molecular Biology and Oncogenetics Papi Júnior Street, 1222, Rodolfo Teófilo 60351-010, Fortaleza, Ceará, Brazil paulo_goberlanio@yahoo.com.br., Barreto GA, Carlos AC, Borges MM, Malta CE, Barbosa JV, Crispim AA, Juaçaba SF, Gonzaga-Silva LF |
| المصدر: | Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2024 May 01; Vol. 29 (3), pp. e398-e407. Date of Electronic Publication: 2024 May 01. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medicina Oral S.L Country of Publication: Spain NLM ID: 101231694 Publication Model: Electronic Cited Medium: Internet ISSN: 1698-6946 (Electronic) Linking ISSN: 16984447 NLM ISO Abbreviation: Med Oral Patol Oral Cir Bucal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Valencia, España : Medicina Oral S.L., [2004]- |
| مواضيع طبية MeSH: | Dysgeusia*/chemically induced , Dysgeusia*/epidemiology , Neoplasms*/drug therapy , Neoplasms*/complications , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/therapeutic use, Humans ; Cross-Sectional Studies ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Survival Rate ; Aged, 80 and over ; Young Adult ; Adolescent |
| مستخلص: | Background: Chemotherapy (CT) is a systemic treatment using a combination of antineoplastic drugs, orally or intravenously, that inhibit tumor growth and fast-growing normal cells. Due to its nonspecificity, chemotherapy can cause a series of adverse effects, such as altered taste (dysgeusia), associated with malnutrition and, consequently, other adverse effects in the gastrointestinal tract and increased mortality risk. This study aimed to evaluate the influence of dysgeusia on the incidence of other adverse effects and overall survival during antineoplastic chemotherapy. Material and Methods: An observational, retrospective, cross-sectional study was conducted using data from the Electronic Health Record system of the Cancer Institute of Ceará over two years. Before the CT session, the multi-professional team evaluated the patient for the presence and severity of adverse effects (AE), using scores from the CTCAE v5.0 scale. Dysgeusia scores were collected and associated with clinical pathological data, with other adverse effects (nausea, vomiting, diarrhea, oral mucositis, anorexia, constipation), and with overall survival. Chi-square and Mantel-Cox log-rank tests were used. Results: Of 5744 patients evaluated, dysgeusia presented a frequency of 50.6%, being directly associated with female gender (p=0.001), overweight (p=0.022), high tumor stages (p=0.009), a combination of adjuvant and neoadjuvant (p=0.010) and four-year survival (p=0.030). Dysgeusia frequency was directly associated with diarrhea (p<0.001), anorexia (p<0.001), oral mucositis (p<0.001), nausea (p<0.001), constipation (p<0.001) and vomiting (p<0.001), and inversely associated with fatigue (p=0.035). Conclusions: Dysgeusia during CT increases the risk of other adverse effects and negatively impacts prognosis. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240414 Date Completed: 20240725 Latest Revision: 20240725 |
| رمز التحديث: | 20240726 |
| مُعرف محوري في PubMed: | PMC11175576 |
| DOI: | 10.4317/medoral.26389 |
| PMID: | 38615256 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1698-6946 |
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| DOI: | 10.4317/medoral.26389 |