دورية أكاديمية
Effect of coadministration of 10 mg/kg calcium chloride and neostigmine on extubation time: A randomized controlled trial.
| العنوان: | Effect of coadministration of 10 mg/kg calcium chloride and neostigmine on extubation time: A randomized controlled trial. |
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| المؤلفون: | Elkenany S; Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Alseoudy MM; Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: drs3ody.mansora@mans.edu.eg., Elshehawi ME; Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Bakrey S; Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Aboelela M; Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt. |
| المصدر: | Revista espanola de anestesiologia y reanimacion [Rev Esp Anestesiol Reanim (Engl Ed)] 2024 Jun-Jul; Vol. 71 (6), pp. 438-444. Date of Electronic Publication: 2024 Apr 12. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 101778594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2341-1929 (Electronic) Linking ISSN: 23411929 NLM ISO Abbreviation: Rev Esp Anestesiol Reanim (Engl Ed) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Barcelona : Elsevier España, 2015- |
| مواضيع طبية MeSH: | Neostigmine*/administration & dosage , Neostigmine*/pharmacology , Calcium Chloride*/administration & dosage , Calcium Chloride*/pharmacology , Airway Extubation* , Anesthesia Recovery Period* , Neuromuscular Blockade*, Humans ; Double-Blind Method ; Male ; Middle Aged ; Female ; Adult ; Prospective Studies ; Time Factors ; Young Adult ; Adolescent ; Aged ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/pharmacology |
| مستخلص: | Introduction and Objectives: Some studies investigating the effect of calcium on neostigmine-induced recovery of neuromuscular blockade have shown that this combination promotes neuromuscular recovery, but does not significantly affect the incidence of postoperative residual curarization and time to extubation. This study aimed to evaluate the effects of 10 mg/kg calcium chloride co-administered with neostigmine on early recovery and time to extubation. Patients and Methods: This prospective, randomized, double-blinded, placebo-controlled study included 88 ASA I-II patients aged between 18 and 65 years who were scheduled for elective surgery lasting at least 1 h under general anaesthesia in which 10 mg/kg of calcium chloride or the same volume of normal saline was co-administered with 5 μg/kg of neostigmine at the end of surgery. Time to extubation (time from neostigmine administration to extubation), time from neostigmine administration to TOF ratio (TOFr) 0.9 (neuromuscular recovery), and the incidence of residual neuromuscular blockade (RNMB) and other adverse effects were recorded. Results: Median (Q1, Q3) extubation time was significantly shorter in the calcium group vs. the placebo group (6.5 min [5.52-7.43] vs. 9.78 min [8.35-11]), P < .001. Median neuromuscular recovery time in the calcium group was 5 min vs. 7.1 min in the placebo group, P < .001. Patients in the calcium group had significantly higher TOFr and lower incidence of RNMB at 5 and 10 min vs. the placebo group, and no significant side effects. Conclusion: Calcium chloride at a dose of 10 mg/kg co-administered with neostigmine promotes early neuromuscular recovery and reduces time to extubation by about 32%. (Copyright © 2024 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bloqueo neuromuscular residual; Calcium chloride; Cloruro cálcico; Extubation time; Neostigmina; Neostigmine; Neuromuscular recovery; Recuperación neuromuscular; Residual neuromuscular block; Tiempo hasta la extubación |
| المشرفين على المادة: | 3982TWQ96G (Neostigmine) M4I0D6VV5M (Calcium Chloride) 0 (Cholinesterase Inhibitors) |
| تواريخ الأحداث: | Date Created: 20240414 Date Completed: 20240620 Latest Revision: 20240827 |
| رمز التحديث: | 20240827 |
| DOI: | 10.1016/j.redare.2024.04.004 |
| PMID: | 38615713 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2341-1929 |
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| DOI: | 10.1016/j.redare.2024.04.004 |