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Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis.

التفاصيل البيبلوغرافية
العنوان: Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis.
المؤلفون: Roy JC; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France; Centre d'Investigation Clinique 1414, Centre Hospitalier Universitaire de Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Rennes, France; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France. Electronic address: jc.roy@ch-guillaumeregnier.fr., Hédouin R; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France., Desmidt T; CHU de Tours, Tours, France; UMR 1253, iBrain, Université de Tours, INSERM, Tours, France; Centre d'Investigation Clinique 1415, CHU de Tours, INSERM, Tours, France., Dam S; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France., Mirea-Grivel I; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France., Weyl L; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France., Bannier E; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France; CHU de Rennes, Service de Radiologie, Rennes, France., Barantin L; CHU de Tours, Tours, France; UMR 1253, iBrain, Université de Tours, INSERM, Tours, France., Drapier D; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France; Centre d'Investigation Clinique 1414, Centre Hospitalier Universitaire de Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Rennes, France; Faculté de Médecine, Rennes Université, Rennes, France., Batail JM; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France; Centre d'Investigation Clinique 1414, Centre Hospitalier Universitaire de Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Rennes, France; Faculté de Médecine, Rennes Université, Rennes, France., David R; CHU de Nice, Université Côte d'Azur, Nice, France., Coloigner J; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France., Robert GH; Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France; Centre d'Investigation Clinique 1414, Centre Hospitalier Universitaire de Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Rennes, France; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France; Faculté de Médecine, Rennes Université, Rennes, France.
المصدر: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2024 Jul; Vol. 9 (7), pp. 639-649. Date of Electronic Publication: 2024 Apr 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier, Inc., [2016]-
مواضيع طبية MeSH: Apathy*/physiology , Magnetic Resonance Imaging* , Brain*/physiopathology , Brain*/diagnostic imaging, Humans ; Female ; Male ; Aged ; Connectome ; Diffusion Tensor Imaging ; Middle Aged ; Nerve Net/physiopathology ; Nerve Net/diagnostic imaging ; Depression/physiopathology ; Depression/diagnostic imaging ; Aged, 80 and over
مستخلص: Background: Better understanding apathy in late-life depression would help improve prediction of poor prognosis of diseases such as dementia. Actimetry provides an objective and ecological measure of apathy from patients' daily motor activity. We aimed to determine whether patterns of motor activity were associated with apathy and brain connectivity in networks that underlie goal-directed behaviors.
Methods: Resting-state functional magnetic resonance imaging and diffusion magnetic resonance imaging were collected from 38 nondemented participants with late-life depression. Apathy was evaluated using the diagnostic criteria for apathy, Apathy Evaluation Scale, and Apathy Motivation Index. Functional principal components (fPCs) of motor activity were derived from actimetry recordings taken for 72 hours. Associations between fPCs and apathy were estimated by linear regression. Subnetworks whose connectivity was significantly associated with fPCs were identified via threshold-free network-based statistics. The relationship between apathy and microstructure metrics was estimated along fibers by diffusion tensor imaging and a multicompartment model called neurite orientation dispersion and density imaging via tractometry.
Results: We found 2 fPCs associated with apathy: mean diurnal activity, negatively associated with Apathy Evaluation Scale scores, and an early chronotype, negatively associated with Apathy Motivation Index scores. Mean diurnal activity was associated with increased connectivity in the default mode, cingulo-opercular, and frontoparietal networks, while chronotype was associated with a more heterogeneous connectivity pattern in the same networks. We did not find significant associations between microstructural metrics and fPCs.
Conclusions: Our findings suggest that mean diurnal activity and chronotype could provide indirect ambulatory measures of apathy in late-life depression, associated with modified functional connectivity of brain networks that underlie goal-directed behaviors.
(Copyright © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Accelerometry; Apathy; Diffusion-weighted imaging (DWI); Geriatric psychiatry; Major depressive disorder; Resting-state functional magnetic resonance imaging (rs-fMRI)
تواريخ الأحداث: Date Created: 20240414 Date Completed: 20240705 Latest Revision: 20240705
رمز التحديث: 20240706
DOI: 10.1016/j.bpsc.2024.04.002
PMID: 38615911
قاعدة البيانات: MEDLINE
الوصف
تدمد:2451-9030
DOI:10.1016/j.bpsc.2024.04.002