دورية أكاديمية
Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion.
| العنوان: | Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion. |
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| المؤلفون: | Long JH; Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China., Wang PJ; Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China., Xuan L; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Juan Y; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Wu GY; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Teng JF; Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China., Sui JF; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China., Li YM; Institute of Economics and Business Management, Chongqing University of Education, Chongqing, China., Yang L; Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China., Li HL; Experimental Center of Basic Medicine, College of Basic Medical Sciences, Army Medical University, Chongqing 400038, China. Electronic address: lihongli@tmmu.edu.cn., Liu SL; Southwest Hospital Jiangbei Area (The 958th hospital of Chinese People's Liberation Army), Chongqing, China. Electronic address: 778591004@qq.com. |
| المصدر: | Behavioural brain research [Behav Brain Res] 2024 Jun 25; Vol. 468, pp. 114999. Date of Electronic Publication: 2024 Apr 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Pruritus*/physiopathology , Nucleus Accumbens*/physiology , Nucleus Accumbens*/drug effects , Rats, Sprague-Dawley* , Neural Pathways*/physiology , Neural Pathways*/physiopathology, Animals ; Male ; Rats ; Disease Models, Animal ; Neurons/physiology ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Prefrontal Cortex/physiology ; Prefrontal Cortex/metabolism ; Proto-Oncogene Proteins c-fos/metabolism |
| مستخلص: | Itch is one of the most common clinical symptoms in patients with diseases of the skin, liver, or kidney, and it strongly triggers aversive emotion and scratching behavior. Previous studies have confirmed the role of the prelimbic cortex (Prl) and the nucleus accumbens core (NAcC), which are reward and motivation regulatory centers, in the regulation of itch. However, it is currently unclear whether the Prl-NAcC projection, an important pathway connecting these two brain regions, is involved in the regulation of itch and its associated negative emotions. In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of itch-scratching behavior by mediating the negative emotions related to itch. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Brain mechanism; Conditioned place aversion; Itch; Nucleus accumbens; Prelimbic cortex; Rats |
| المشرفين على المادة: | 0 (Proto-Oncogene Proteins c-fos) |
| تواريخ الأحداث: | Date Created: 20240414 Date Completed: 20240524 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| DOI: | 10.1016/j.bbr.2024.114999 |
| PMID: | 38615978 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7549 |
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| DOI: | 10.1016/j.bbr.2024.114999 |