دورية أكاديمية
Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice via regulation of intestinal flora and lipopolysaccharide-related signaling pathways.
| العنوان: | Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice via regulation of intestinal flora and lipopolysaccharide-related signaling pathways. |
|---|---|
| المؤلفون: | Chen L; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn.; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, China., Lei Y; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn., Lu C; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn., Liu D; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn., Ma W; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn., Lu H; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn.; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, China., Wang Y; School of Life Sciences, Anhui University, Hefei, China. yzwang@ahu.edu.cn.; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, China.; Anhui Key Laboratory of Modern Biomanufacturing, Hefei, China. |
| المصدر: | Food & function [Food Funct] 2024 May 07; Vol. 15 (9), pp. 5012-5025. Date of Electronic Publication: 2024 May 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*/drug effects , Hyperlipidemias*/drug therapy , Signal Transduction*/drug effects , Obesity*/metabolism , Obesity*/drug therapy , Mice, Inbred C57BL* , Linolenic Acids*/pharmacology , Lipopolysaccharides*, Animals ; Mice ; Male ; Diet, High-Fat ; Non-alcoholic Fatty Liver Disease/drug therapy ; Pomegranate/chemistry ; Liver/metabolism ; Liver/drug effects ; Oxidative Stress/drug effects |
| مستخلص: | Punicic acid (PA), mainly found in pomegranate seed oil (PSO), has attracted increasing attention due to its potential to mitigate obesity. The regulation of intestinal microflora was identified as a crucial factor and an effective strategy to reverse obesity-related hyperlipidemia and non-alcoholic fatty liver disease (NAFLD). To assess the impact of PSO on hyperlipidemia related to obesity, we investigated the hepatic lipid status and gut microbiota regulation in mice over 13 weeks of feeding a high-fructose high-fat diet (HFHFD). Serum lipid markers, including TG, TC and LDL-C, were markedly reduced in hyperlipidemic mice. PSO supplementation reduced hepatic lipid accumulation and steatosis, inhibited the expression of pro-inflammatory mediators (including IL-6 and IL-1β), and restored the normal levels of the anti-inflammatory cytokine IL-10. In addition, PSO also alleviated oxidative stress and increased T-AOC and SOD activities, as well as GSH levels, while reducing the MDA content in the liver of HFHFD-fed mice. The activation of TLR4/MyD88/NF-κB and TLR4/IL-22/STAT3 signaling pathways in the liver due to the HFHFD was also evidently inhibited by PSO. Furthermore, supplementation of PSO ameliorated the HFHFD-induced dysbiosis of intestinal microflora, resulting in a markedly increased proportion of Muribaculaceae , a decreased ratio of Blautia , and elevated levels of microbiota-derived short-chain fatty acids (SCFAs). Moreover, the expression of tight junction proteins correlated with intestinal barrier function was notably restored in the colon. The collected results indicate that PSO may be an effective nutraceutical ingredient for attenuating lipid metabolic disorders. |
| المشرفين على المادة: | VFQ03H211O (punicic acid) 0 (Linolenic Acids) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20240415 Date Completed: 20240507 Latest Revision: 20240507 |
| رمز التحديث: | 20240507 |
| DOI: | 10.1039/d4fo00502c |
| PMID: | 38618675 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
|---|---|
| DOI: | 10.1039/d4fo00502c |