دورية أكاديمية
Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster .
| العنوان: | Syagrus coronata fixed oil prevents rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster . |
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| المؤلفون: | Dos Santos Nunes RG; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil., de Amorim LC; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil., Bezerra IC; Keizo Asami Institute, iLIKA, Federal University of Pernambuco, Recife, Brazil., da Silva AJ; Keizo Asami Institute, iLIKA, Federal University of Pernambuco, Recife, Brazil., Dos Santos CAL; Department of Biological Sciences, Regional University of Cariri, Crato, Ceará, Brazil., Gubert P; Keizo Asami Institute, iLIKA, Federal University of Pernambuco, Recife, Brazil., de Menezesa IRA; Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará, Brazil., Duarte AE; Postgraduate Program in Pure and Applied Chemistry, Federal University of Western of Bahia, Bahia, Brazil., Barros LM; Postgraduate Program in Pure and Applied Chemistry, Federal University of Western of Bahia, Bahia, Brazil., da Silveira Andrade-da-Costa BL; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil., Dos Santos MV; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil., Dos Santos Correia MT; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil., da Rosa MM; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil.; Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Suely-Galdino Therapeutic Innovation Research Center (NUPIT-SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil. |
| المصدر: | Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2024 Jun 17; Vol. 87 (12), pp. 497-515. Date of Electronic Publication: 2024 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-7394 (Print) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. ; London : Taylor & Francis, c1998- |
| مواضيع طبية MeSH: | Rotenone* , Movement Disorders*, Animals ; Drosophila melanogaster ; Molecular Docking Simulation ; Oxidative Stress ; Antioxidants/pharmacology ; Nitric Oxide/metabolism |
| مستخلص: | One prominent aspect of Parkinson's disease (PD) is the presence of elevated levels of free radicals, including reactive oxygen species (ROS). Syagrus coronata ( S. coronata) , a palm tree, exhibits antioxidant activity attributed to its phytochemical composition, containing fatty acids, polyphenols, and flavonoids. The aim of this investigation was to examine the potential neuroprotective effects of S. coronata fixed oil against rotenone-induced toxicity using Drosophila melanogaster . Young Drosophila specimens (3-4 d old) were exposed to a diet supplemented with rotenone (50 µM) for 7 d with and without the inclusion of S. coronata fixed oil (0.2 mg/g diet). Data demonstrated that rotenone exposure resulted in significant locomotor impairment and increased mortality rates in flies. Further, rotenone administration reduced total thiol levels but elevated lipid peroxidation, iron (Fe) levels, and nitric oxide (NO) levels while decreasing the reduced capacity of mitochondria. Concomitant administration of S. coronata exhibited a protective effect against rotenone, as evidenced by a return to control levels of Fe, NO, and total thiols, lowered lipid peroxidation levels, reversed locomotor impairment, and enhanced % cell viability. Molecular docking of the oil lipidic components with antioxidant enzymes showed strong binding affinity to superoxide dismutase (SOD) and glutathione peroxidase (GPX1) enzymes. Overall, treatment with S. coronata fixed oil was found to prevent rotenone-induced movement disorders and oxidative stress in Drosophila melanogaster . |
| فهرسة مساهمة: | Keywords: Drosophila melanogaster; Natural product; Syagrus coronata fixed oil; antioxidant activity; rotenone |
| المشرفين على المادة: | 03L9OT429T (Rotenone) 0 (Antioxidants) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20240415 Date Completed: 20240419 Latest Revision: 20240419 |
| رمز التحديث: | 20240419 |
| DOI: | 10.1080/15287394.2024.2338431 |
| PMID: | 38619158 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1528-7394 |
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| DOI: | 10.1080/15287394.2024.2338431 |