دورية أكاديمية
Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.
العنوان: | Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen. |
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المؤلفون: | Kovach MA; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden. makovach@umich.edu., Käck U; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs´ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Che KF; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden., Brundin B; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden., Konradsen JR; Department of Medicine Solna Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Lindén A; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden.; Karolinska Severe COPD Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden. |
المصدر: | Respiratory research [Respir Res] 2024 Apr 15; Vol. 25 (1), pp. 163. Date of Electronic Publication: 2024 Apr 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2001- : London : BioMed Central Ltd. Original Publication: London : Current Science Ltd., c2000- |
مواضيع طبية MeSH: | Asthma*/diagnosis , Asthma*/drug therapy, Animals ; Child ; Dogs ; Humans ; Allergens ; Biomarkers ; Interleukin-17 ; Interleukins |
مستخلص: | Background: Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children. Methods: Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded. Results: The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17 A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations. Conclusion: This study forwards evidence that systemic IL-26, just like IL-17 A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target. (© 2024. The Author(s).) |
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المشرفين على المادة: | 0 (Allergens) 0 (Biomarkers) 0 (Interleukin-17) 0 (Interleukins) 0 (IL26 protein, human) |
تواريخ الأحداث: | Date Created: 20240415 Date Completed: 20240417 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC11020994 |
DOI: | 10.1186/s12931-024-02773-7 |
PMID: | 38622712 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1465-993X |
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DOI: | 10.1186/s12931-024-02773-7 |