دورية أكاديمية
أعرض في EDS

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.

التفاصيل البيبلوغرافية
العنوان: Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.
المؤلفون: Kovach MA; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden. makovach@umich.edu., Käck U; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Sachs´ Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden., Che KF; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden., Brundin B; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden., Konradsen JR; Department of Medicine Solna Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Lindén A; Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden.; Karolinska Severe COPD Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
المصدر: Respiratory research [Respir Res] 2024 Apr 15; Vol. 25 (1), pp. 163. Date of Electronic Publication: 2024 Apr 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : London : BioMed Central Ltd.
Original Publication: London : Current Science Ltd., c2000-
مواضيع طبية MeSH: Asthma*/diagnosis , Asthma*/drug therapy, Animals ; Child ; Dogs ; Humans ; Allergens ; Biomarkers ; Interleukin-17 ; Interleukins
مستخلص: Background: Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children.
Methods: Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA. Self-reported history, including medication use and validated symptom-based questionnaire scores, was recorded.
Results: The serum concentrations of IL-26 were enhanced in allergen-sensitized subjects and correlated with those of IL-17 A in a positive manner. However, the IL-26 concentrations did not markedly differ between allergen-sensitized subjects with and without asthma, eczema, allergic rhinitis, or a history of food allergy. Notably, IL-26 concentrations correlated with increasing Asthma Control Test (ACT) scores in a positive manner and with inhaled corticosteroid in a negative manner, amongst sensitized subjects with asthma. Moreover, subjects with asthma requiring ≥ 1 course of oral corticosteroids in the preceding 12 months had decreased IL-26 concentrations.
Conclusion: This study forwards evidence that systemic IL-26, just like IL-17 A, is involved in allergen sensitization among children. The association of systemic IL-26 with improved asthma control is compatible with the cellular sources being recruited into the airways in severe asthma, which supports that this kinocidin bears potential as a biomarker and therapeutic target.
(© 2024. The Author(s).)
References: Respir Res. 2016 Mar 31;17:32. (PMID: 27029915)
Adv Respir Med. 2022 Jan 27;:. (PMID: 35084725)
Cytokine. 2024 Jan;173:156452. (PMID: 38039695)
Cochrane Database Syst Rev. 2017 Sep 21;9:CD010834. (PMID: 28933516)
Int Arch Allergy Immunol. 2001 Nov;126(3):179-84. (PMID: 11752873)
Expert Rev Respir Med. 2019 Nov;13(11):1057-1068. (PMID: 31498708)
J Allergy Clin Immunol. 2006 Mar;117(3):549-56. (PMID: 16522452)
Cytokine Growth Factor Rev. 2021 Feb;57:1-10. (PMID: 33293237)
Qual Life Res. 1996 Feb;5(1):35-46. (PMID: 8901365)
Am J Respir Crit Care Med. 2014 Nov 1;190(9):1022-31. (PMID: 25291379)
Front Immunol. 2021 Oct 28;12:761317. (PMID: 34777376)
J Asthma Allergy. 2020 Feb 03;13:95-107. (PMID: 32099415)
Cytokine. 2020 Oct;134:155206. (PMID: 32683104)
Front Pharmacol. 2019 Aug 30;10:956. (PMID: 31543817)
Genes Immun. 2012 Sep;13(6):481-8. (PMID: 22622197)
J Allergy Clin Immunol. 2004 Jan;113(1):59-65. (PMID: 14713908)
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302. (PMID: 24200404)
J Innate Immun. 2016;8(1):15-22. (PMID: 26202572)
Mol Med. 2017 Oct;23:247-257. (PMID: 28853490)
Cells. 2022 Jul 06;11(14):. (PMID: 35883573)
Dis Mon. 2020 Apr;66(4):100886. (PMID: 31570159)
Clin Transl Allergy. 2022 May 02;12(5):e12149. (PMID: 35510076)
Nat Immunol. 2007 Sep;8(9):950-7. (PMID: 17676044)
PLoS One. 2017 Dec 5;12(12):e0188909. (PMID: 29206862)
Mol Immunol. 2023 May;157:1-7. (PMID: 36947935)
Nat Immunol. 2015 Sep;16(9):970-9. (PMID: 26168081)
J Allergy Clin Immunol. 2018 Oct;142(4):1113-1120.e9. (PMID: 29852259)
J Allergy Clin Immunol. 2019 Oct;144(4):1134-1136.e10. (PMID: 31288043)
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):1161-1173. (PMID: 31785165)
Int J Chron Obstruct Pulmon Dis. 2018 Aug 24;13:2569-2575. (PMID: 30197513)
Expert Rev Respir Med. 2022 Mar;16(3):293-301. (PMID: 35188435)
Pediatr Ann. 2019 Mar 1;48(3):e128-e134. (PMID: 30874821)
N Engl J Med. 2017 Sep 7;377(10):936-946. (PMID: 28877011)
Clin Sci (Lond). 2018 May 20;132(9):959-983. (PMID: 29780024)
Allergy. 2006 Apr;61(4):454-60. (PMID: 16512808)
J Immunol. 2002 Jun 1;168(11):5397-402. (PMID: 12023331)
المشرفين على المادة: 0 (Allergens)
0 (Biomarkers)
0 (Interleukin-17)
0 (Interleukins)
0 (IL26 protein, human)
تواريخ الأحداث: Date Created: 20240415 Date Completed: 20240417 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11020994
DOI: 10.1186/s12931-024-02773-7
PMID: 38622712
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا