دورية أكاديمية
أعرض في EDS

Predictors for liver fibrosis in non-alcoholic patients with psoriatic diseases: A multicenter cross sectional-study.

التفاصيل البيبلوغرافية
العنوان: Predictors for liver fibrosis in non-alcoholic patients with psoriatic diseases: A multicenter cross sectional-study.
المؤلفون: Chavez-Tapia NC; Obesity and Digestive Diseases Unit and Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico., Sanchez-Jimenez BA; Endoscopy Department, National Institute of Cancer, Mexico City, Mexico., Vidaña-Perez D; Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico., Corrales-Rosas B; Hospital de Especialidades, Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social, Mexico City, Mexico., Balderas-Garces B; Obesity and Digestive Diseases Unit and Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico., Vera-Izaguirre D; Dermatology Department, Dr. Manuel Gea González General Hospital, Mexico City, Mexico., Santa Cruz FJ; Dr. Ladislao de la Pascua' Dermatologic Center, Secretaria de Salud del Distrito Federal, Mexico City, Mexico., Maldonado-Garcia C; Dr. Ladislao de la Pascua' Dermatologic Center, Secretaria de Salud del Distrito Federal, Mexico City, Mexico., Juarez-Hernandez E; Obesity and Digestive Diseases Unit and Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico., Uribe M; Obesity and Digestive Diseases Unit and Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
المصدر: PloS one [PLoS One] 2024 Apr 16; Vol. 19 (4), pp. e0290632. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
نوع المنشور: Multicenter Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Non-alcoholic Fatty Liver Disease*/complications , Non-alcoholic Fatty Liver Disease*/epidemiology , Non-alcoholic Fatty Liver Disease*/diagnosis , Psoriasis*/complications , Psoriasis*/epidemiology , Elasticity Imaging Techniques*/methods, Humans ; Cross-Sectional Studies ; gamma-Glutamyltransferase ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/diagnosis ; Fibrosis
مستخلص: Psoriasis has been related to metabolic dysfunction-associated fatty liver disease and, liver fibrosis. This study aimed to evaluate the prevalence of liver fibrosis in psoriasis and identify predictors for fibrosis. This is a cross-sectional study conducted from December 2012 to June 2016 assessing psoriasis and psoriatic arthritis patients attended at four centers in Mexico City. Data regarding history of the skin disease, previous and current medication, and previously diagnosed liver disease was collected. Liver fibrosis was assessed with four different non-invasive methods (FIB4, APRI, NAFLD score and elastography). We compared data based on the presence of fibrosis. Adjusted-logistic regression models were performed to estimate OR and 95% CI. A total of 160 patients were included. The prevalence of significant fibrosis using elastography was 25% (n = 40), and 7.5% (n = 12) for advanced fibrosis. Patients with fibrosis had higher prevalence of obesity (60% vs 30.8%, P = 0.04), type 2 diabetes (40% vs 27.5%, P = 0.003), gamma-glutamyl transpeptidase levels (70.8±84.4 vs. 40.1±39.2, P = 0.002), and lower platelets (210.7±58.9 vs. 242.8±49.7, P = 0.0009). Multivariate analysis showed that body mass index (OR1.11, 95%CI 1.02-1.21), type 2 diabetes (OR 3.44, 95%CI 1.2-9.88), and gamma-glutamyl transpeptidase (OR 1.01, 95%CI1-1.02) were associated with the presence of fibrosis. The use of methotrexate was not associated. Patients with psoriasis are at higher risk of fibrosis. Metabolic dysfunction, rather than solely the use of hepatotoxic drugs, likely plays a major role; it may be beneficial to consider elastography regardless of the treatment used. Metabolic factors should be assessed, and lifestyle modification should be encouraged.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Chavez-Tapia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: EC 2.3.2.2 (gamma-Glutamyltransferase)
تواريخ الأحداث: Date Created: 20240416 Date Completed: 20240418 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11020486
DOI: 10.1371/journal.pone.0290632
PMID: 38626012
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0290632