Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency.

التفاصيل البيبلوغرافية
العنوان:	Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency.
المؤلفون:	Villar-Gouy KR; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Salmon CEG; Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.; Department of Medical Imaging, Hematology and Clinical Oncology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Salvatori R; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine Baltimore, Maryland, 21287, USA., Kellner M; Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany., Krauss MPO; Centro de Medicina Integrada de Sergipe (CEMISE), Aracaju, SE, 49020-365, Brazil., Rocha TO; Centro de Medicina Integrada de Sergipe (CEMISE), Aracaju, SE, 49020-365, Brazil., de Souza EA; Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Batista VO; Division of Psychiatry, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil., Leal ÂC; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Santos LB; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Melo EV; Statistics Division, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil., Oliveira-Santos AA; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Oliveira CRP; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Campos VC; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Santos EG; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Santana NO; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Pereira FA; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil., Amorim RS; Division of Geriatrics, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil., Donato-Junior J; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-900, Brazil., Filho JASB; Division of Cardiology, Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, 49060-100, Brazil., Santos AC; Department of Medical Imaging, Hematology and Clinical Oncology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Health Sciences Graduate Program, Federal University of Sergipe, Street Claudio Batista s/n, Aracaju, Sergipe, 49060-100, Brazil. herminio.endo@gmail.com.
المصدر:	Journal of endocrinological investigation [J Endocrinol Invest] 2024 Apr 16. Date of Electronic Publication: 2024 Apr 16.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2014- : Berlin : Springer Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis.
مستخلص:	Purpose: Individuals with isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene have a normal life expectancy and above 50 years of age, similar total cognitive performance, with better attention and executive function than controls. Our objectives were to evaluate their brain morphometry and brain aging using MRI. Methods: Thirteen IGHD and 14 controls matched by age, sex, and education, were enrolled. Quantitative volumetric data and cortical thickness were obtained by automatic segmentation using Freesurfer software. The volume of each brain region was normalized by the intracranial volume. The difference between the predicted brain age estimated by MRI using a trained neuronal network, and the chronological age, was obtained. p < 0.005 was considered significant and 0.005 < p < 0.05 as a suggestive evidence of difference. Results: In IGHD, most absolute values of cortical thickness and regional brain volumes were similar to controls, but normalized volumes were greater in the white matter in the frontal pole and in the insula bilaterally, and in the gray matter, in the right insula and in left Caudate (p < 0.005 for all comparisons) We also noticed suggestive evidence of a larger volume in IGHD in left thalamus (p = 0.006), right thalamus (p = 0.025), right caudate (p = 0.046) and right putamen (p = 0.013). Predicted brain ages were similar between groups. Conclusion: IGHD is primarily associated with similar absolute brain measurements, and a set of larger normalized volumes, and does not appear to alter the process of brain aging. (© 2024. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
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معلومات مُعتمدة:	307576/2022-1. Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة:	Keywords: Aging; Brain; GH; GHRH receptor; Magnetic resonance imaging
تواريخ الأحداث:	Date Created: 20240416 Latest Revision: 20240416
رمز التحديث:	20240417
DOI:	10.1007/s40618-024-02372-9
PMID:	38627331
قاعدة البيانات:	MEDLINE

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تدمد:	1720-8386
DOI:	10.1007/s40618-024-02372-9