دورية أكاديمية
Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia.
العنوان: | Aerobic vaginitis is associated with carbonic anhydrase IX in cervical intraepithelial neoplasia. |
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المؤلفون: | Grincevičienė Š; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio Av. 7, 10257, Vilnius, Lithuania. svitrigaile.grinceviciene@bti.vu.lt., Vaitkienė D; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu St. 2, 50161, Kaunas, Lithuania., Kanopienė D; Consultative Polyclinic Department, National Cancer Institute, Santariskiu St. 1, 08406, Vilnius, Lithuania., Vansevičiūtė Petkevičienė R; Consultative Polyclinic Department, National Cancer Institute, Santariskiu St. 1, 08406, Vilnius, Lithuania.; Clinic of Obstetrics and Gynecology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, M. K. Ciurlionio St. 21, 03101, Vilnius, Lithuania., Sukovas A; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu St. 2, 50161, Kaunas, Lithuania., Celiešiūtė J; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu St. 2, 50161, Kaunas, Lithuania., Ivanauskaitė Didžiokienė E; National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, P. Baublio St. 5, 08406, Vilnius, Lithuania., Čižauskas A; Department of Pathological Anatomy, Medical Academy, Lithuanian University of Health Sciences, Eiveniu St. 2, 50161, Kaunas, Lithuania., Laurinavičienė A; National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, P. Baublio St. 5, 08406, Vilnius, Lithuania.; Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Institute of Biomedical Science, Vilnius University, M. K. Ciurlionio St. 21, 03101, Vilnius, Lithuania., Stravinskienė D; Department of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio Av. 7, 10257, Vilnius, Lithuania., Grincevičius J; Faculty of Medicine, Pharmacy and Pharmacology Center, Institute of Biomedical Science, Vilnius University, M. K. Ciurlionio St. 21, 03101, Vilnius, Lithuania., Matulis D; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio Av. 7, 10257, Vilnius, Lithuania., Matulienė J; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio Av. 7, 10257, Vilnius, Lithuania. |
المصدر: | Scientific reports [Sci Rep] 2024 Apr 16; Vol. 14 (1), pp. 8789. Date of Electronic Publication: 2024 Apr 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Papillomavirus Infections*/complications , Uterine Cervical Dysplasia*/pathology , Uterine Cervical Neoplasms*/pathology , Vulvovaginitis*, Female ; Humans ; Carbonic Anhydrase IX ; Conization ; Papillomaviridae |
مستخلص: | The aim of this study was to analyze the association between vaginal microbiota, carbonic anhydrase IX (CAIX) and histological findings of cervical intraepithelial neoplasia (CIN). The study included 132 females, among them 66 were diagnosed with high-grade intraepithelial lesion (CIN2, CIN3, and cancer), 14 with low-grade disease, and 52 assigned to the control group. An interview focused on the behavior risk factors, together with vaginal fluid pH measurement, wet mount microscopy, detection of Chlamydia trachomatis, and Trichomonas vaginalis were performed. After colposcopy, high-grade abnormalities were detected via direct biopsies and treated with conization procedure. Conuses were immuno-stained with CAIX antibody. The histological findings were CIN1 (n = 14), and CIN2+ (included CIN2 (n = 10), CIN3 (n = 49), and cancer (n = 7; squamous cell carcinomas)). Prevalence of bacterial vaginosis (BV) was similar between the groups. Moderate or severe aerobic vaginitis (msAV) was diagnosed more often among CIN2+ (53.0%) than CIN1 (21.4%). Moderate or strong immunostaining of CAIX (msCAIX) was not detected among CIN1 cases. Thus, msAV was prevalent in CAIX non-stained group (p = 0.049) among CIN2 patients. Co-location of msAV and msCAIX was found in CIN3. Regression model revealed that msAV associated with high-grade cervical intraepithelial neoplasia independently from smoking and the number of partners. (© 2024. The Author(s).) |
References: | PLoS One. 2015 Mar 04;10(3):e0119181. (PMID: 25738958) Clin Lab Med. 2014 Dec;34(4):747-61. (PMID: 25439274) JAMA. 1994 Apr 20;271(15):1181-8. (PMID: 8151876) Pathogens. 2023 Nov 14;12(11):. (PMID: 38003814) Epidemiol Infect. 2018 Oct;146(13):1714-1723. (PMID: 29923470) Urology. 2010 Feb;75(2):257-61. (PMID: 19963243) Eur J Cancer. 2010 Jan;46(2):405-11. (PMID: 19819687) PLoS One. 2012;7(10):e45201. (PMID: 23056195) Am J Reprod Immunol. 2014 Jun;71(6):555-63. (PMID: 24832618) Carcinogenesis. 2010 Nov;31(11):1905-12. (PMID: 20819779) Infect Dis Obstet Gynecol. 1996;4(1):2-6. (PMID: 18476056) Infect Dis Obstet Gynecol. 1999;7(4):177-9. (PMID: 10449264) Eur J Obstet Gynecol Reprod Biol. 2007 Oct;134(2):220-4. (PMID: 16952417) J Low Genit Tract Dis. 2016 Jul;20(3):213-7. (PMID: 27203702) Front Immunol. 2021 Jan 14;11:606721. (PMID: 33519815) Med Arch. 2013;67(2):94-6. (PMID: 24341052) J Clin Invest. 2016 Oct 3;126(10):3689-3698. (PMID: 27525434) N Engl J Med. 2021 Nov 11;385(20):1856-1867. (PMID: 34534429) Vaccine. 2022 Nov 15;40(48):6947-6955. (PMID: 36283897) J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033. (PMID: 29865880) Pathol Res Pract. 2019 Apr;215(4):705-711. (PMID: 30638861) Biology (Basel). 2021 Jul 26;10(8):. (PMID: 34439947) Am J Clin Pathol. 2014 Feb;141(2):219-25. (PMID: 24436269) Vaccines (Basel). 2022 Apr 09;10(4):. (PMID: 35455328) Int J Radiat Oncol Biol Phys. 2009 Jun 1;74(2):553-61. (PMID: 19427557) Br J Cancer. 2010 May 25;102(11):1627-35. (PMID: 20461082) PLoS Pathog. 2017 Apr 6;13(4):e1006211. (PMID: 28384274) Gynecol Oncol. 2010 Mar;116(3):452-8. (PMID: 19913895) Sci Rep. 2022 Sep 13;12(1):15397. (PMID: 36100684) Obstet Gynecol. 2012 Dec;120(6):1465-71. (PMID: 23168774) Nat Commun. 2020 Apr 24;11(1):1999. (PMID: 32332850) Sci Rep. 2018 May 15;8(1):7593. (PMID: 29765068) Mol Carcinog. 2019 Mar;58(3):388-397. (PMID: 30362630) Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):355-73. (PMID: 17434799) Metabolites. 2018 Feb 10;8(1):. (PMID: 29439394) Perspect Clin Res. 2018 Oct-Dec;9(4):184-186. (PMID: 30319950) Sci Rep. 2021 Feb 3;11(1):2898. (PMID: 33536516) Int J Mol Sci. 2021 Jun 05;22(11):. (PMID: 34198834) Cancers (Basel). 2021 Mar 09;13(5):. (PMID: 33803236) J Infect Dis. 2004 Apr 15;189(8):1348-54. (PMID: 15073670) Biomolecules. 2019 Jul 25;9(8):. (PMID: 31349673) Public Health. 1994 Jul;108(4):241-9. (PMID: 8066168) PLoS One. 2018 Jul 2;13(7):e0199476. (PMID: 29965974) Obstet Gynecol. 2010 Dec;116(6):1373-1380. (PMID: 21099605) BJOG. 2011 Sep;118(10):1163-70. (PMID: 21668769) Nurs Outlook. 2012 Jul-Aug;60(4):182-90. (PMID: 22789450) Int J Clin Oncol. 2015 Feb;20(1):126-33. (PMID: 24578180) Future Virol. 2011 Jan 1;6(1):45-57. (PMID: 21318095) Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1954-9. (PMID: 20647411) Cells. 2021 Mar 23;10(3):. (PMID: 33807087) BJOG. 2002 Jan;109(1):34-43. (PMID: 11845812) Am J Epidemiol. 2008 Jul 15;168(2):123-37. (PMID: 18483125) Prev Med. 2021 Dec;153:106827. (PMID: 34599922) Nat Commun. 2018 Nov 29;9(1):5071. (PMID: 30498244) J Med Virol. 2015 Mar;87(3):461-71. (PMID: 25196501) J Cancer Res Clin Oncol. 2006 May;132(5):302-8. (PMID: 16416108) Front Oncol. 2021 Jul 19;11:665595. (PMID: 34350111) Minerva Obstet Gynecol. 2021 Apr;73(2):233-246. (PMID: 33140628) BMC Cancer. 2011 Jan 11;11:12. (PMID: 21223596) Eur J Obstet Gynecol Reprod Biol. 2009 Jul;145(1):109-12. (PMID: 19481329) Eur J Clin Microbiol Infect Dis. 2016 Apr;35(4):657-64. (PMID: 26810061) PLoS One. 2018 Jul 16;13(7):e0200855. (PMID: 30011326) Front Cell Infect Microbiol. 2020 Sep 25;10:569022. (PMID: 33102255) Diagnostics (Basel). 2021 Jan 09;11(1):. (PMID: 33435407) Commun Biol. 2022 Jul 22;5(1):725. (PMID: 35869172) |
معلومات مُعتمدة: | S-SEN-20-10 Lietuvos Mokslo Taryba |
فهرسة مساهمة: | Keywords: Aerobic vaginitis; CAIX enzyme; Carbonic anhydrase 9; Cervical intraepithelial neoplasia; Microbiota alteration; Uterine cervix dysplasia |
المشرفين على المادة: | EC 4.2.1.1 (Carbonic Anhydrase IX) EC 4.2.1.1 (CA9 protein, human) |
تواريخ الأحداث: | Date Created: 20240416 Date Completed: 20240418 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC11021548 |
DOI: | 10.1038/s41598-024-57427-x |
PMID: | 38627429 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-024-57427-x |