دورية أكاديمية
A spatiotemporal atlas of mouse liver homeostasis and regeneration.
| العنوان: | A spatiotemporal atlas of mouse liver homeostasis and regeneration. |
|---|---|
| المؤلفون: | Xu J; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Guo P; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China. guopengcheng@genomics.cn.; 3DC STAR, Spatiotemporal Campus at BGI Shenzhen, Shenzhen, China. guopengcheng@genomics.cn., Hao S; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Shangguan S; BGI Research, Shenzhen, China.; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China., Shi Q; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Volpe G; Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Huang K; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Zuo J; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., An J; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Yuan Y; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Cheng M; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Deng Q; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Zhang X; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China., Lai G; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China.; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Nan H; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Wu B; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Shentu X; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Wu L; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Wei X; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Jiang Y; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Huang X; BGI Research, Shenzhen, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China., Pan F; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Song Y; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Li R; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Wang Z; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Liu C; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China.; BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China., Liu S; BGI Research, Hangzhou, China.; BGI Research, Shenzhen, China., Li Y; BGI Research, Shenzhen, China., Yang T; China National GeneBank, BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGI Research, Shenzhen, China., Xu Z; China National GeneBank, BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGI Research, Shenzhen, China., Du W; China National GeneBank, BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGI Research, Shenzhen, China., Li L; China National GeneBank, BGI Research, Shenzhen, China.; Guangdong Provincial Genomics Data Center, BGI Research, Shenzhen, China., Ahmed T; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., You K; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Dai Z; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Li L; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Qin B; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Li Y; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Lai L; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Qin D; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Research Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen J; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China., Fan R; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China., Li Y; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China., Hou J; Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China., Ott M; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Sharma AD; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Cantz T; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Schambach A; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Kristiansen K; Department of Biology, University of Copenhagen, Copenhagen, Denmark., Hutchins AP; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China., Göttgens B; Department of Haematology and Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Maxwell PH; Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK., Hui L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China., Xu X; BGI Research, Hangzhou, China. xuxun@genomics.cn.; BGI Research, Shenzhen, China. xuxun@genomics.cn.; BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China. xuxun@genomics.cn.; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, China. xuxun@genomics.cn., Liu L; BGI Research, Hangzhou, China. liulongqi@genomics.cn.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China. liulongqi@genomics.cn.; BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China. liulongqi@genomics.cn., Chen A; BGI Research, Shenzhen, China. chenao@genomics.cn.; Department of Biology, University of Copenhagen, Copenhagen, Denmark. chenao@genomics.cn.; BGI Research, Chongqing, China. chenao@genomics.cn.; JFL-BGI STOmics Center, BGI-Shenzhen, Chongqing, China. chenao@genomics.cn., Lai Y; BGI Research, Hangzhou, China. laiyiwei@genomics.cn.; BGI Research, Shenzhen, China. laiyiwei@genomics.cn.; 3DC STAR, Spatiotemporal Campus at BGI Shenzhen, Shenzhen, China. laiyiwei@genomics.cn.; BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan, China. laiyiwei@genomics.cn., Esteban MA; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China. miguelesteban@genomics.cn.; 3DC STAR, Spatiotemporal Campus at BGI Shenzhen, Shenzhen, China. miguelesteban@genomics.cn.; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. miguelesteban@genomics.cn.; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. miguelesteban@genomics.cn.; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Research Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. miguelesteban@genomics.cn.; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany. miguelesteban@genomics.cn. |
| المصدر: | Nature genetics [Nat Genet] 2024 May; Vol. 56 (5), pp. 953-969. Date of Electronic Publication: 2024 Apr 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Co., c1992- |
| مواضيع طبية MeSH: | Liver Regeneration*/genetics , Homeostasis* , Liver*/metabolism , Wnt Signaling Pathway*/genetics, Animals ; Mice ; Hepatocytes/metabolism ; Hepatocytes/cytology ; Cell Proliferation/genetics ; Single-Cell Analysis ; Gene Regulatory Networks ; Gene Expression Profiling/methods ; Transcriptome ; Mice, Inbred C57BL ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Male |
| مستخلص: | The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale. Our integrative study dissects in detail the molecular gradients controlling liver cell function, systematically defining how gene networks are dynamically modulated through intercellular communication to promote regeneration. Among other important regulators, we identified the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/β-catenin signaling for facilitating hepatocyte proliferation. Our data and analytical pipelines lay the foundation for future high-definition tissue-scale atlases of organ physiology and malfunction. (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
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| معلومات مُعتمدة: | 32370848 National Natural Science Foundation of China (National Science Foundation of China); 92168202 National Natural Science Foundation of China (National Science Foundation of China); 32200688 National Natural Science Foundation of China (National Science Foundation of China) |
| تواريخ الأحداث: | Date Created: 20240416 Date Completed: 20240516 Latest Revision: 20240520 |
| رمز التحديث: | 20240521 |
| DOI: | 10.1038/s41588-024-01709-7 |
| PMID: | 38627598 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1546-1718 |
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| DOI: | 10.1038/s41588-024-01709-7 |