دورية أكاديمية
Metabolic programming of organ-specific natural killer cell responses.
العنوان: | Metabolic programming of organ-specific natural killer cell responses. |
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المؤلفون: | Delconte RB; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Sun JC; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, New York, USA. |
المصدر: | Immunological reviews [Immunol Rev] 2024 May; Vol. 323 (1), pp. 8-18. Date of Electronic Publication: 2024 Apr 17. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002-> : Oxford : Blackwell Original Publication: Copenhagen, Munksgaard. |
مواضيع طبية MeSH: | Killer Cells, Natural*/immunology , Killer Cells, Natural*/metabolism, Humans ; Animals ; Immunity, Innate ; Organ Specificity/immunology ; Neoplasms/immunology ; Neoplasms/metabolism ; Energy Metabolism ; Tumor Microenvironment/immunology ; Homeostasis ; Cytokines/metabolism ; Metabolic Reprogramming |
مستخلص: | Cells of the mammalian innate immune system have evolved to protect the host from various environmental or internal insults and injuries which perturb the homeostatic state of the organism. Among the lymphocytes of the innate immune system are natural killer (NK) cells, which circulate and survey host tissues for signs of stress, including infection or transformation. NK cells rapidly eliminate damaged cells in the blood or within tissues through secretion of cytolytic machinery and production of proinflammatory cytokines. To perform these effector functions while traversing between the blood and tissues, patrolling NK cells require sufficient fuel to meet their energetic demands. Here, we highlight the ability of NK cells to metabolically adapt across tissues, during times of nutrient deprivation and within tumor microenvironments. Whether at steady state, or during viral infection and cancer, NK cells readily shift their nutrient uptake and usage in order to maintain metabolism, survival, and function. (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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معلومات مُعتمدة: | R01 AI100874 United States AI NIAID NIH HHS; AI155558 United States HI NHLBI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; United States CRI Cancer Research Institute; AI100874 United States HI NHLBI NIH HHS; National Health and Medical Research Council; AI130043 United States HI NHLBI NIH HHS; P30CA008748 United States HI NHLBI NIH HHS; R01 AI155558 United States AI NIAID NIH HHS; Burroughs Wellcome Fund; Parker Institute for Cancer Immunotherapy; American Cancer Society; R01 AI130043 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: NK cells; cancer; immunity; immunometabolism |
تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240517 Latest Revision: 20240520 |
رمز التحديث: | 20240520 |
مُعرف محوري في PubMed: | PMC11102308 |
DOI: | 10.1111/imr.13333 |
PMID: | 38628147 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1600-065X |
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DOI: | 10.1111/imr.13333 |