دورية أكاديمية
Francisella tularensis- specific antibody levels in sera from Swedish patients with suspected tularemia during a 13-year period.
| العنوان: | Francisella tularensis- specific antibody levels in sera from Swedish patients with suspected tularemia during a 13-year period. |
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| المؤلفون: | Lindgren H; Department of Clinical Microbiology, Umeå University, Umeå, Sweden., Liu X; Umeå School of Business, Economics and Statistics, Umeå University, Umeå, Sweden., Sjöstedt A; Department of Clinical Microbiology, Umeå University, Umeå, Sweden. |
| المصدر: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Apr 02; Vol. 14, pp. 1381776. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA |
| مواضيع طبية MeSH: | Francisella tularensis* , Tularemia*/diagnosis , Tularemia*/epidemiology, Humans ; Sweden/epidemiology ; Retrospective Studies ; Antibodies, Bacterial ; Immunoglobulin M ; Immunoglobulin G |
| مستخلص: | Introduction: For a majority of tularemia patients, serology is the basis for the diagnosis. The aim of this study was to perform an analysis of the samples analyzed at a Swedish reference laboratory for the presence of Francisella tularensis-specific antibody levels in sera from individuals with suspected tularemia. Annual and monthly variations of the total number of samples and proportions of positive samples were analyzed, as well as the influence of age and gender. Methods: We performed a retrospective analysis of the presence of F. tularensis-specific antibodies in serological samples from patients with suspected tularemia analyzed during the period 2010 - 2022 at the University Hospital of Umeå in Sweden, a national reference laboratory, by use of various statistical methods. In total, some 15,100 serum samples had been analyzed for the presence of IgG and IgM antibodies by ELISA during the 13-year period. Results: Overall, there were higher number of samples with IgG positive or borderline titers, 2,522 and 921, respectively, than with IgM positive or borderline titers, 1,802 and 409, respectively. Repeated samples were obtained from some 1,930 individuals and approximately a third of the cases, which were initially seronegative, had seroconverted when resampled. Peak number of monthly samples were recorded in August and September, > 3,000. Annual numbers varied greatly and peak numbers were observed in 2015 and 2019, 1,832 and 2,250, respectively, whereas some other years the numbers were 700 - 800. There was also much variation in the annual and monthly percentages of positive samples and they varied between less than 10% to greater than 20%. The highest percentages of positive samples were recorded in September and October. IgG and IgM titers declined with age and these differences were highly significant for IgG titers, with decreasing average titers for each 20-year interval. Discussion: Collectively, the data demonstrate the marked annual and seasonal variations in tularemia sampling occurring in Sweden. Also, the proportion of positive samples increased during months and years with peak number of samples. Another notable finding was that average antibody titers decreased with increased age. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Lindgren, Liu and Sjöstedt.) |
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| فهرسة مساهمة: | Keywords: age-related titers; annual distribution; monthly distribution; serological response; tularemia |
| المشرفين على المادة: | 0 (Antibodies, Bacterial) 0 (Immunoglobulin M) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240418 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC11018962 |
| DOI: | 10.3389/fcimb.2024.1381776 |
| PMID: | 38628552 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2235-2988 |
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| DOI: | 10.3389/fcimb.2024.1381776 |