دورية أكاديمية
A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMIC ® ) over microfracture: 10-year follow-up.
| العنوان: | A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMIC ® ) over microfracture: 10-year follow-up. |
|---|---|
| المؤلفون: | Volz M; Sportklinik Ravensburg, Ravensburg, Germany., Schaumburger J; Department of Orthopedic Surgery, Asklepios Clinical Center Bad Abbach, University of Regensburg, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany., Gellißen J; Radiologische Allianz, Hamburg, Germany., Grifka J; Department of Orthopedic Surgery, Asklepios Clinical Center Bad Abbach, University of Regensburg, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany., Anders S; Department of Orthopedic Surgery, Asklepios Clinical Center Bad Abbach, University of Regensburg, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany. s.anders@asklepios.com. |
| المصدر: | European journal of orthopaedic surgery & traumatology : orthopedie traumatologie [Eur J Orthop Surg Traumatol] 2024 Jul; Vol. 34 (5), pp. 2429-2437. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag France Country of Publication: France NLM ID: 9518037 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1068 (Electronic) Linking ISSN: 16338065 NLM ISO Abbreviation: Eur J Orthop Surg Traumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris : Springer-Verlag France |
| مواضيع طبية MeSH: | Chondrogenesis* , Arthroplasty, Subchondral*/methods , Cartilage, Articular*/surgery , Cartilage, Articular*/injuries, Humans ; Female ; Male ; Follow-Up Studies ; Adult ; Prospective Studies ; Treatment Outcome ; Middle Aged ; Transplantation, Autologous/methods ; Knee Joint/surgery ; Knee Joint/physiopathology ; Chondrocytes/transplantation |
| مستخلص: | Purpose: Autologous matrix-induced chondrogenesis (AMIC ® ) and microfracture are established treatments for focal chondral defects in the knee, but there are little clinical data concerning these procedures over the long term. This study evaluates the outcomes of AMIC ® compared to microfracture over 10-year follow-up. Methods: Forty-seven patients were randomized and treated either with MFx (n = 13), sutured AMIC ® (n = 17) or glued AMIC ® (n = 17) in a prospective, randomized, controlled multicentre trial. The Modified Cincinnati Knee Score, a visual analogue scale for pain and MOCART score were used to assess outcomes over 10 years post-operatively. Results: All treatment arms improved in the first 2 years, but a progressive and significant deterioration in scores was observed in the MFx group, while both AMIC ® groups remained stable. MOCART scores were comparable between groups. Conclusion: The AMIC ® procedure results in improved patient outcomes in comparison with microfracture up to 10 years following surgery for the repair of focal chondral defects in the knee. Clinicaltrials: gov Identifier: NCT02993510. (© 2024. The Author(s).) |
| References: | J Bone Joint Surg Am. 2016 Aug 17;98(16):1332-9. (PMID: 27535435) J Clin Med. 2019 Mar 21;8(3):. (PMID: 30901900) Open Orthop J. 2013 May 03;7:133-43. (PMID: 23730377) Surg Technol Int. 2020 Nov 28;37:341-347. (PMID: 33197956) Z Orthop Unfall. 2023 Feb;161(1):57-64. (PMID: 35189656) Am J Sports Med. 2012 Nov;40(11):2487-91. (PMID: 22972851) Am J Sports Med. 2021 Jan;49(1):193-199. (PMID: 33226845) Int Orthop. 2017 Apr;41(4):797-804. (PMID: 28108777) Clin Orthop Relat Res. 2001 Oct;(391 Suppl):S362-9. (PMID: 11603719) Int J Surg. 2019 Aug;68:56-62. (PMID: 31220632) Am J Sports Med. 2023 Feb;51(2):367-378. (PMID: 36661257) Am J Sports Med. 2023 Jul;51(8):2193-2206. (PMID: 35736251) Orthop J Sports Med. 2019 Sep 17;7(9):2325967119868212. (PMID: 31555714) J Bone Joint Surg Br. 1961 Nov;43-B:752-7. (PMID: 14038135) Front Cell Dev Biol. 2022 Jan 03;9:787118. (PMID: 35047499) Knee. 2023 Jun;42:320-338. (PMID: 37148615) Eur J Radiol. 2006 Jan;57(1):16-23. (PMID: 16203119) Cartilage. 2017 Apr;8(2):131-138. (PMID: 28345403) Arthroscopy. 2015 Apr;31(4):746-54. (PMID: 25617008) Cartilage. 2021 Dec;13(1_suppl):1124S-1136S. (PMID: 32715735) Arthroscopy. 2016 Jul;32(7):1444-50. (PMID: 27129375) Am J Sports Med. 2020 Apr;48(5):1134-1140. (PMID: 32181674) Orthop J Sports Med. 2021 Feb 26;9(2):2325967120981872. (PMID: 33738308) Am J Sports Med. 2018 Mar;46(4):826-831. (PMID: 29253350) Cartilage. 2021 Dec;13(1_suppl):639S-645S. (PMID: 32741215) Life (Basel). 2021 Feb 25;11(3):. (PMID: 33669015) Cartilage. 2010 Jan;1(1):29-42. (PMID: 26069534) Cartilage. 2021 Dec;13(1_suppl):42S-56S. (PMID: 31508990) |
| فهرسة مساهمة: | Keywords: AMIC®; Cartilage; Chondral; Knee; Microfracture; RCT; Repair |
| سلسلة جزيئية: | ClinicalTrials.gov NCT02993510 |
| تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240731 Latest Revision: 20240803 |
| رمز التحديث: | 20240803 |
| مُعرف محوري في PubMed: | PMC11291581 |
| DOI: | 10.1007/s00590-024-03948-0 |
| PMID: | 38630297 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1068 |
|---|---|
| DOI: | 10.1007/s00590-024-03948-0 |