دورية أكاديمية
Changes in Induced-Antipredation Defense Traits and Transcriptome Regulations of Daphnia magna in Response to 5-HT 1A Receptor Antagonist.
| العنوان: | Changes in Induced-Antipredation Defense Traits and Transcriptome Regulations of Daphnia magna in Response to 5-HT |
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| المؤلفون: | Liu Q; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China., Deng Z; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China., Chen H; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China., Kim MS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Kim DH; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Gu L; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China., Lee JS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Yang Z; Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Biological Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China. |
| المصدر: | Environmental science & technology [Environ Sci Technol] 2024 Apr 30; Vol. 58 (17), pp. 7577-7587. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington DC : American Chemical Society Original Publication: Easton, Pa. : American Chemical Society, c1967- |
| مواضيع طبية MeSH: | Daphnia magna*/drug effects , Transcriptome*/drug effects , Serotonin 5-HT1 Receptor Agonists*/pharmacology, Animals ; Predatory Behavior |
| مستخلص: | The serotonin signaling system plays a crucial role in regulating the ontogeny of crustaceans. Here, we describe the effects of different concentrations of the 5-hydroxytryptamine 1A receptor antagonist (WAY-100635) on the induced antipredation ( Rhodeus ocellatus as the predator), morphological, behavioral, and life-history defenses of Daphnia magna and use transcriptomics to analyze the underlying molecular mechanisms. Our results indicate that exposure to WAY-100635 leads to changes in the expression of different defensive traits in D. magna when faced with fish predation risks. Specifically, as the length of exposure to WAY-100635 increases, high concentrations of WAY-100635 inhibit defensive responses associated with morphological and reproductive activities but promote the immediate negative phototactic behavioral defense of D. magna . This change is related to the underlying mechanism through which WAY-100635 interferes with gene expression of G-protein-coupled GABA receptors by affecting GABBR1 but promotes serotonin receptor signaling and ecdysteroid signaling pathways. In addition, we also find for the first time that fish kairomone can significantly activate the HIF-1α signaling pathway, which may lead to an increase in the rate of immediate movement. These results can help assess the potential impacts of serotonin-disrupting psychotropic drugs on zooplankton in aquatic ecosystems. |
| فهرسة مساهمة: | Keywords: 5-HT1A receptor antagonist; Daphina magna; inducible defense; kairomone; serotonin |
| المشرفين على المادة: | 0 (Serotonin 5-HT1 Receptor Agonists) |
| تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240430 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1021/acs.est.3c10720 |
| PMID: | 38630542 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5851 |
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| DOI: | 10.1021/acs.est.3c10720 |