دورية أكاديمية
Oxidized sodium alginate hydrogel-mouse nerve growth factor sustained release system promotes repair of peripheral nerve injury.
| العنوان: | Oxidized sodium alginate hydrogel-mouse nerve growth factor sustained release system promotes repair of peripheral nerve injury. |
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| المؤلفون: | Sun Y; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Sun X; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Wang R; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Xing Y; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Ma X; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Yue J; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Zhang M; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Wang Y; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China., Tian W; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Jing G; Medical College, First Affiliated Hospital of Harbin Medical University, Harbin, China. |
| المصدر: | Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2024 Jul; Vol. 35 (10), pp. 1550-1570. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor and Francis Country of Publication: England NLM ID: 9007393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5624 (Electronic) Linking ISSN: 09205063 NLM ISO Abbreviation: J Biomater Sci Polym Ed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : Abingdon, Oxon : Taylor and Francis Original Publication: Utrecht, The Netherlands : VSP, c1989- |
| مواضيع طبية MeSH: | Alginates*/chemistry , Alginates*/pharmacology , Nerve Growth Factor*/chemistry , Delayed-Action Preparations*/chemistry , Hydrogels*/chemistry , Hydrogels*/pharmacology , Peripheral Nerve Injuries*/drug therapy , Peripheral Nerve Injuries*/metabolism , Drug Liberation*, Animals ; Mice ; Rats ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Sciatic Nerve/injuries ; Sciatic Nerve/drug effects ; Nerve Regeneration/drug effects ; Oxidation-Reduction ; Cell Line ; Male ; Rats, Sprague-Dawley ; Drug Carriers/chemistry ; Phosphatidylinositol 3-Kinases/metabolism |
| مستخلص: | In recent years, mouse nerve growth factor (mNGF) has emerged as an important biological regulator to repair peripheral nerve injury, but its systemic application is restricted by low efficiency and large dosage requirement. These limitations prompted us to search for biomaterials that can be locally loaded. Oxidized sodium alginate hydrogel (OSA) exhibits good biocompatibility and physicochemical properties, and can be loaded with drugs to construct a sustained-release system that can act locally on nerve injury. Here, we constructed a sustained-release system of OSA-mouse nerve growth factor (mNGF), and investigated the loading and release of the drug through Fourier transform infrared spectroscopy and drug release curves. In vitro and in vivo experiments showed that OSA-mNGF significantly promoted the biological activities of RSC-96 cells and facilitated the recovery from sciatic nerve crush injury in rats. This observation may be attributed to the additive effect of OSA on promoting Schwann cell biological activities or its synergistic effect of cross-activating phosphoinositide 3-kinase (PI3K) through extracellular signal regulated kinase (ERK) signaling. Although the specific mechanism of OSA action needs to be explored in the future, the current results provide a valuable preliminary research basis for the clinical application of the OSA-mNGF sustained-release system for nerve repair. |
| فهرسة مساهمة: | Keywords: Oxidized sodium alginate hydrogel (OSA); mouse nerve growth factor (mNGF); peripheral nerve injury; sustained drug release |
| المشرفين على المادة: | 0 (Alginates) 9061-61-4 (Nerve Growth Factor) 0 (Delayed-Action Preparations) 0 (Hydrogels) 0 (Drug Carriers) EC 2.7.1.- (Phosphatidylinositol 3-Kinases) |
| تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240625 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1080/09205063.2024.2339636 |
| PMID: | 38630632 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5624 |
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| DOI: | 10.1080/09205063.2024.2339636 |