التفاصيل البيبلوغرافية
| العنوان: |
Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia. |
| المؤلفون: |
Hu X; Department of Neurosurgery, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China., Ma YN; Department of Gastroenterology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China., Xia Y; Department of Neurosurgery, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China. |
| المصدر: |
Bioscience trends [Biosci Trends] 2024 Jun 06; Vol. 18 (2), pp. 195-197. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: International Research and Cooperation Association for Bio & Socio-Sciences Advancement Country of Publication: Japan NLM ID: 101502754 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-7823 (Electronic) Linking ISSN: 18817815 NLM ISO Abbreviation: Biosci Trends Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Tokyo : International Research and Cooperation Association for Bio & Socio-Sciences Advancement |
| مواضيع طبية MeSH: |
Microglia*/metabolism , Alzheimer Disease*/genetics , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Apolipoprotein E4*/genetics , Apolipoprotein E4*/metabolism , Lipid Metabolism*/genetics , Genotype*, Humans ; Animals |
| مستخلص: |
APOE4 is widely recognized as a genetic risk factor for Alzheimer's disease (AD), implicated in 60-80% of all AD cases. Recent research suggests that microglia carrying the APOE4 genotype display abnormal lipid metabolism and accumulate lipid droplets, which may exacerbate the pathology of AD. Microglia play a critical role in immune surveillance within the central nervous system and are responsible for removing harmful particles and preserving neuronal function. The APOE4 genotype causes abnormal lipid metabolism in microglia, resulting in excessive accumulation of lipid droplets. This accumulation not only impairs the phagocytic and clearance capabilities of microglia but also disrupts their interactions with neurons, resulting in disorganization and neurodegenerative alterations at the neuronal network level. In addition, the presence of APOE4 modifies the metabolic landscape of microglia, particularly affecting purinergic signaling and lipid metabolism, thereby exacerbating the pathological processes of AD. In conclusion, the accumulation of lipid droplets and abnormal lipid metabolism may be critical mechanisms in the progression of AD in microglia carrying the APOE4 genotype. |
| فهرسة مساهمة: |
Keywords: APOE4; Alzheimer's disease; apolipoprotein E; lipid metabolism; microglia |
| المشرفين على المادة: |
0 (Apolipoprotein E4) |
| تواريخ الأحداث: |
Date Created: 20240417 Date Completed: 20240605 Latest Revision: 20240605 |
| رمز التحديث: |
20240606 |
| DOI: |
10.5582/bst.2024.01092 |
| PMID: |
38631884 |
| قاعدة البيانات: |
MEDLINE |
