دورية أكاديمية
Risk Factors for Mortality in Patients with Stenotrophomonas maltophilia Bloodstream Infections in Immunocompetent Patients.
| العنوان: | Risk Factors for Mortality in Patients with Stenotrophomonas maltophilia Bloodstream Infections in Immunocompetent Patients. |
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| المؤلفون: | Menekşe Ş; Infection Control Unit, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey., Altınay E; Department of Anesthesia, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey., Oğuş H; Department of Anesthesia, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey., Kaya Ç; Infection Control Unit, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey., Işık ME; Infection Control Unit, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey., Kırali K; Department of Cardiovascular Surgery, Kartal Koşuyolu Heart and Research Hospital, İstanbul, Turkey. |
| المصدر: | Infectious diseases & clinical microbiology [Infect Dis Clin Microbiol] 2022 Sep 26; Vol. 4 (3), pp. 178-184. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Doc Design and Informatics Co. Ltd Country of Publication: Turkey NLM ID: 9918680988406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2667-646X (Electronic) Linking ISSN: 2667646X NLM ISO Abbreviation: Infect Dis Clin Microbiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: İstanbul, Turkey : Doc Design and Informatics Co. Ltd., [2019]- |
| مستخلص: | Objective: This study aimed to evaluate bloodstream infections caused by Stenotrophomonas maltophilia in immunocompetent patients with respect to clinical features and risk factors for mortality. Methods: We reviewed bloodstream infections detected between January 1, 2012, and July 1, 2021, to identify nosocomial S. maltophilia bacteremia in Koşuyolu Research and Training Hospital. Results: We identified a total of 97 patients with S. maltophilia bloodstream infections. Of these, 17 patients were excluded because of community-acquired infections (n=9), contamination with S. maltophilia (n=3), and insufficient data (n=5), with 80 (57.5% males) patients remaining for analysis. The source of infection was the respiratory tract in 28 (35%) patients. A central venous catheter was used in 60 (75%) patients, which required replacement in 23 patients within five days after detecting S. maltophilia bacteremia. On antimicrobial susceptibility testing, 71 strains were found to be susceptible and 9 (11.3%) resistant to trimethoprim-sulfamethoxazole. Thirty-day mortality was 33.8%. Non-survivors differed significantly from survivors with respect to higher rates of central venous catheters ( p =0.020), mechanical ventilation ( p =0.006), urinary catheters ( p =0.021), septic shock ( p =0.001), hypoalbuminemia ( p =0.026) and thrombocytopenia ( p =0.039). S. maltophilia bacteremia was independently associated with mortality in patients with hypoalbuminemia, and replacement of central venous catheters had a protective role in reducing mortality. Conclusion: As with other bacterial infections, S. maltophilia bacteremia is associated with a considerably high mortality rate in patients with cardiac conditions. The replacement of the catheter seems to play a beneficial role in 30-day survival. Competing Interests: The authors declare no conflict of interest. (Copyright © 2024 Infectious Diseases and Clinical Microbiology.) |
| References: | BMC Infect Dis. 2019 Aug 28;19(1):754. (PMID: 31462215) Jundishapur J Microbiol. 2015 Aug 22;8(8):e23569. (PMID: 26468367) JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338) Am J Infect Control. 2023 May;51(5):533-538. (PMID: 35868456) Biomed Res Int. 2019 Dec 9;2019:4931501. (PMID: 31886220) J Clin Med. 2022 May 30;11(11):. (PMID: 35683471) Isr Med Assoc J. 2022 Jul;24(7):454-459. (PMID: 35819214) Diseases. 2019 May 31;7(2):. (PMID: 31159258) Medicine (Baltimore). 2016 Aug;95(31):e4375. (PMID: 27495046) Open Forum Infect Dis. 2020 Jan 19;7(1):ofaa008. (PMID: 32016126) Cureus. 2021 Oct 20;13(10):e18916. (PMID: 34812302) Infection. 2020 Apr;48(2):205-212. (PMID: 31686323) J Hosp Infect. 2008 Oct;70(2):101-8. (PMID: 18621440) Clin Microbiol Rev. 2021 Jun 16;34(3):e0003019. (PMID: 34043457) JAC Antimicrob Resist. 2022 May 05;4(3):dlac040. (PMID: 35529051) J Hosp Infect. 2012 Jun;81(2):114-8. (PMID: 22494851) |
| فهرسة مساهمة: | Keywords: Stenotrophomonas maltophilia; bloodstream infections; mortality |
| تواريخ الأحداث: | Date Created: 20240418 Latest Revision: 20240419 |
| رمز التحديث: | 20240419 |
| مُعرف محوري في PubMed: | PMC10986715 |
| DOI: | 10.36519/idcm.2022.173 |
| PMID: | 38633400 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2667-646X |
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| DOI: | 10.36519/idcm.2022.173 |