دورية أكاديمية
Commensal microbiota regulate aldosterone.
| العنوان: | Commensal microbiota regulate aldosterone. |
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| المؤلفون: | Moore BN; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States., Medcalf AD; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States., Muir RQ; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States., Xu C; School of Biological Sciences, Faculty of Medicine, Monash University, Clayton, Victoria, Australia., Marques FZ; School of Biological Sciences, Faculty of Medicine, Monash University, Clayton, Victoria, Australia., Pluznick JL; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States. |
| المصدر: | American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2024 Jun 01; Vol. 326 (6), pp. F1032-F1038. Date of Electronic Publication: 2024 Apr 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society, c1997- |
| مواضيع طبية MeSH: | Aldosterone*/blood , Aldosterone*/metabolism , Gastrointestinal Microbiome*/drug effects , Renin*/blood , Renin*/metabolism , Mice, Inbred C57BL*, Animals ; Female ; Male ; Blood Pressure/drug effects ; Germ-Free Life ; Mice ; Anti-Bacterial Agents/pharmacology ; Hypertension/microbiology ; Hypertension/metabolism |
| مستخلص: | The gut microbiome regulates many important host physiological processes associated with cardiovascular health and disease; however, the impact of the gut microbiome on aldosterone is unclear. Investigating whether gut microbiota regulate aldosterone can offer novel insights into how the microbiome affects blood pressure. In this study, we aimed to determine whether gut microbiota regulate host aldosterone. We used enzyme-linked immunosorbent assays (ELISAs) to assess plasma aldosterone and plasma renin activity (PRA) in female and male mice in which gut microbiota are intact, suppressed, or absent. In addition, we examined urinary aldosterone. Our findings demonstrated that when the gut microbiota is suppressed following antibiotic treatment, there is an increase in plasma and urinary aldosterone in both female and male mice. In contrast, an increase in PRA is seen only in males. We also found that when gut microbiota are absent (germ-free mice), plasma aldosterone is significantly increased compared with conventional animals (in both females and males), but PRA is not. Understanding how gut microbiota influence aldosterone levels could provide valuable insights into the development and treatment of hypertension and/or primary aldosteronism. This knowledge may open new avenues for therapeutic interventions, such as probiotics or dietary modifications to help regulate blood pressure via microbiota-based changes to aldosterone. NEW & NOTEWORTHY We explore the role of the gut microbiome in regulating aldosterone, a hormone closely linked to blood pressure and cardiovascular disease. Despite the recognized importance of the gut microbiome in host physiology, the relationship with circulating aldosterone remains largely unexplored. We demonstrate that suppression of gut microbiota leads to increased levels of plasma and urinary aldosterone. These findings underscore the potential of the gut microbiota to influence aldosterone regulation, suggesting new possibilities for treating hypertension. |
| معلومات مُعتمدة: | R01DK137762 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: RAAS; aldosterone; gut microbiome; renal physiology |
| المشرفين على المادة: | 4964P6T9RB (Aldosterone) EC 3.4.23.15 (Renin) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240530 Latest Revision: 20240530 |
| رمز التحديث: | 20240530 |
| DOI: | 10.1152/ajprenal.00051.2024 |
| PMID: | 38634136 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1466 |
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| DOI: | 10.1152/ajprenal.00051.2024 |