دورية أكاديمية
Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway.
| العنوان: | Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway. |
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| المؤلفون: | Wang WD; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Zeng CY; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Shang Y; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Ni J; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Li GJ; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Li LP; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Xi SH; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China., Chen SZ; Department of Cancer Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China.; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. |
| المصدر: | Journal of Asian natural products research [J Asian Nat Prod Res] 2024 Aug; Vol. 26 (8), pp. 945-954. Date of Electronic Publication: 2024 Apr 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Newark, N.J.?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Triple Negative Breast Neoplasms*/drug therapy , Signal Transduction*/drug effects , Smad3 Protein*/metabolism , Smad2 Protein*/metabolism, Humans ; Female ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; Cell Line, Tumor ; Molecular Structure ; Down-Regulation/drug effects ; Cell Survival/drug effects |
| مستخلص: | Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiostrepton in TNBC. Thiostrepton inhibited MDA-MB-231 cell viability, accompanied by a decrease of c-FLIP and p-SMAD2/3. c-FLIP overexpression reduced the sensitivity of MDA-MB-231 cells to thiostrepton, while SMAD2/3 knockdown increased the sensitivity of MDA-MB-231 cells to thiostrepton. Moreover, c-FLIP overexpression significantly increased the expression and phosphorylation of SMAD2/3 proteins and vice versa. In conclusion, our study reveals c-FLIP/SMAD2/3 signaling pathway as a novel mechanism of antitumor activity of thiostrepton. |
| فهرسة مساهمة: | Keywords: SMAD2/3; Thiostrepton; c-FLIP; triple-negative breast cancer (TNBC) |
| المشرفين على المادة: | 0 (Smad3 Protein) 0 (Smad2 Protein) 0 (CASP8 and FADD-Like Apoptosis Regulating Protein) 0 (SMAD2 protein, human) 0 (SMAD3 protein, human) |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240626 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1080/10286020.2024.2343420 |
| PMID: | 38634704 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2213 |
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| DOI: | 10.1080/10286020.2024.2343420 |