دورية أكاديمية
Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning.
| العنوان: | Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning. |
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| المؤلفون: | Rangel Guerrero DK; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria. Electronic address: dama.ketino@gmail.com., Balueva K; Institute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany., Barayeu U; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria., Baracskay P; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria., Gridchyn I; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria., Nardin M; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria., Roth CN; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria., Wulff P; Institute of Physiology, Christian-Albrechts-University Kiel, 24118 Kiel, Germany. Electronic address: p.wulff@physiologie.uni-kiel.de., Csicsvari J; Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria. Electronic address: jozsef.csicsvari@ist.ac.at. |
| المصدر: | Neuron [Neuron] 2024 Jun 19; Vol. 112 (12), pp. 2045-2061.e10. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Cholecystokinin*/metabolism , Cholecystokinin*/genetics , Hippocampus*/physiology , Interneurons*/physiology , Interneurons*/metabolism , Optogenetics* , Pyramidal Cells*/physiology , Pyramidal Cells*/metabolism, Animals ; Male ; Mice ; CA1 Region, Hippocampal/physiology ; CA1 Region, Hippocampal/cytology ; CA1 Region, Hippocampal/metabolism ; Fear/physiology ; Learning/physiology ; Maze Learning/physiology ; Memory/physiology ; Mental Recall/physiology ; Mice, Inbred C57BL ; Mice, Transgenic ; Theta Rhythm/physiology |
| مستخلص: | Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs revealed a heterogeneous population, and their optogenetic silencing triggered wide disinhibitory network changes affecting both pyramidal cells and other interneurons. CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding of place cells: theta phase precession was disrupted, whereas sequence reactivation was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial reference memories on the Morris water maze but enhanced the recall of contextual fear memories and enabled selective recall when similar environments were tested. This work suggests the key involvement of CCKIs in the control of place-cell temporal coding and the formation of contextual memories. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CA1 CCK interneuron; GABAergic modulation; chemogenetics; memory; optogenetics; oscillations; place cell coding; sharp-wave ripple; theta phase precession; trajectory replay |
| المشرفين على المادة: | 9011-97-6 (Cholecystokinin) EC 2.7.11.1 (Ripk2 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240620 Latest Revision: 20240710 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1016/j.neuron.2024.03.019 |
| PMID: | 38636524 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2024.03.019 |