دورية أكاديمية
Nisin variants: What makes them different and unique?
| العنوان: | Nisin variants: What makes them different and unique? |
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| المؤلفون: | da Silva Oliveira W; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Teixeira CRV; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Mantovani HC; Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, USA., Dolabella SS; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Jain S; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Barbosa AAT; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil; Programa de Pós-Graduação em Biologia Parasitária, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil. Electronic address: ana.barbosaufs@yahoo.com.br. |
| المصدر: | Peptides [Peptides] 2024 Jul; Vol. 177, pp. 171220. Date of Electronic Publication: 2024 Apr 16. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier Science Inc. Original Publication: Fayetteville, N. Y., Ankho International. |
| مواضيع طبية MeSH: | Nisin*/chemistry , Nisin*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry, Humans ; Animals ; Lactococcus lactis/metabolism ; Lactococcus lactis/genetics ; Cattle ; SARS-CoV-2/drug effects ; COVID-19 Drug Treatment |
| مستخلص: | Nisin A is a lantibiotic bacteriocin typically produced by strains of Lactococcus lactis. This bacteriocin has been approved as a natural food preservative since the late 1980 s and shows antimicrobial activity against a range of food-borne spoilage and pathogenic microorganisms. The therapeutic potential of nisin A has also been explored increasingly both in human and veterinary medicine. Nisin has been shown to be effective in treating bovine mastitis, dental caries, cancer, and skin infections. Recently, it was demonstrated that nisin has an affinity for the same receptor used by SARS-CoV-2 to enter human cells and was proposed as a blocker of the viral infection. Several nisin variants produced by distinct bacterial strains or modified by bioengineering have been described since the discovery of nisin A. These variants present modifications in the peptide structure, biosynthesis, mode of action, and spectrum of activity. Given the importance of nisin for industrial and therapeutic applications, the objective of this study was to describe the characteristics of the nisin variants, highlighting the main differences between these molecules and their potential applications. This review will be useful to researchers interested in studying the specifics of nisin A and its variants. Competing Interests: Declaration of Competing Interest The authors report no declarations of interest. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antimicrobial peptides; Bacteriocins; Biological activity; Biotechnology; Food preservation; Therapy |
| المشرفين على المادة: | 1414-45-5 (Nisin) 0 (Anti-Bacterial Agents) EN8XKG133D (nisin A) |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240601 Latest Revision: 20240601 |
| رمز التحديث: | 20240602 |
| DOI: | 10.1016/j.peptides.2024.171220 |
| PMID: | 38636811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-5169 |
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| DOI: | 10.1016/j.peptides.2024.171220 |