دورية أكاديمية
أعرض في EDS

Different learning aberrations relate to delusion-like beliefs with different contents.

التفاصيل البيبلوغرافية
العنوان: Different learning aberrations relate to delusion-like beliefs with different contents.
المؤلفون: Rossi-Goldthorpe R; Interdepartmental Neuroscience Program, Wu Tsai Institute, Yale University, New Haven, CT 06511, USA.; Department of Psychiatry, Yale University, New Haven, CT 06511, USA., Silverstein SM; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14623, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14623, USA.; Department of Opthalmology, University of Rochester Medical Center, Rochester, NY 14623, USA., Gold JM; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA., Schiffman J; Department of Psychological Sciences, University of California Irvine, Irvine, CA 92617, USA., Waltz JA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA., Williams TF; Department of Psychology, Northwestern University, Evanston, IL 60208-2710, USA., Powers AR; Department of Psychiatry, Yale University, New Haven, CT 06511, USA., Woods SW; Department of Psychiatry, Yale University, New Haven, CT 06511, USA., Zinbarg RE; Department of Psychology, Northwestern University, Evanston, IL 60208-2710, USA., Mittal VA; Department of Psychology, Northwestern University, Evanston, IL 60208-2710, USA., Ellman LM; Department of Psychology and Neuroscience, Temple University, Philadelphia, PA 19122, USA., Strauss GP; Department of Psychology, University of Georgia, Athens, GA 30602, USA., Walker EF; Department of Psychology, Emory University, Atlanta, GA 30322, USA., Levin JA; Department of Psychology, University of Georgia, Athens, GA 30602, USA., Castiello S; Department of Psychiatry, Yale University, New Haven, CT 06511, USA.; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA., Kenney J; Department of Psychiatry, Yale University, New Haven, CT 06511, USA.; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA., Corlett PR; Department of Psychiatry, Yale University, New Haven, CT 06511, USA.; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA.; Department of Psychology, Yale University, New Haven, CT 06511, USA.
المصدر: Brain : a journal of neurology [Brain] 2024 Aug 01; Vol. 147 (8), pp. 2854-2866.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Oxford University Press
Original Publication: London.
مواضيع طبية MeSH: Delusions*/psychology , Paranoid Disorders*/psychology, Humans ; Male ; Female ; Young Adult ; Adult ; Reversal Learning/physiology ; Adolescent ; Culture ; Cues
مستخلص: The prediction error account of delusions has had success. However, its explanation of delusions with different contents has been lacking. Persecutory delusions and paranoia are the common unfounded beliefs that others have harmful intentions towards us. Other delusions include believing that one's thoughts or actions are under external control or that events in the world have specific personal meaning. We compare learning in two different cognitive tasks, probabilistic reversal learning and Kamin blocking, that have relationships to paranoid and non-paranoid delusion-like beliefs, respectively. We find that clinical high-risk status alone does not result in different behavioural results in the probabilistic reversal learning task but that an individual's level of paranoia is associated with excessive switching behaviour. During the Kamin blocking task, paranoid individuals learned inappropriately about the blocked cue. However, they also had decreased learning about the control cue, suggesting more general learning impairments. Non-paranoid delusion-like belief conviction (but not paranoia) was associated with aberrant learning about the blocked cue but intact learning about the control cue, suggesting specific impairments in learning related to cue combination. We fit task-specific computational models separately to behavioural data to explore how latent parameters vary within individuals between tasks and how they can explain symptom-specific effects. We find that paranoia is associated with low learning rates in the probabilistic reversal learning task and the blocking task. Non-paranoid delusion-like belief conviction is instead related to parameters controlling the degree and direction of similarity between cue updating during simultaneous cue presentation. These results suggest that paranoia and other delusion-like beliefs involve dissociable deficits in learning and belief updating, which, given the transdiagnostic status of paranoia, might have differential utility in predicting psychosis.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
References: PLoS One. 2012;7(8):e43905. (PMID: 23028415)
J Neurosci. 2013 Aug 21;33(34):13701-12. (PMID: 23966692)
Schizophr Bull. 2023 Nov 29;49(6):1591-1601. (PMID: 37350507)
PLoS Comput Biol. 2015 Nov 04;11(11):e1004567. (PMID: 26535896)
J Psychiatr Res. 2003 Mar-Apr;37(2):155-63. (PMID: 12842169)
Q J Exp Psychol (Hove). 2010 Jun;63(6):1127-49. (PMID: 20509208)
Behav Pharmacol. 2003 Jul;14(4):315-22. (PMID: 12838037)
Br J Psychol. 2016 Nov;107(4):601-624. (PMID: 26719216)
Neuropsychopharmacology. 2018 Mar;43(4):770-780. (PMID: 28741627)
Cell. 2014 Sep 25;159(1):21-32. (PMID: 25259917)
PLoS Comput Biol. 2021 Oct 7;17(10):e1009453. (PMID: 34618805)
Neuropsychologia. 2012 Dec;50(14):3612-20. (PMID: 23079501)
Elife. 2016 May 02;5:. (PMID: 27136677)
Cogn Sci. 2016 Mar;40(2):404-39. (PMID: 25902728)
J Cogn. 2023 Mar 10;6(1):19. (PMID: 36910583)
Schizophr Res Cogn. 2015 Apr 07;2(2):72-77. (PMID: 29114455)
J Neurosci. 2008 Jun 18;28(25):6295-303. (PMID: 18562599)
Eur Psychiatry. 2019 May;58:72-79. (PMID: 30870626)
Front Hum Neurosci. 2015 Sep 30;9:521. (PMID: 26483654)
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13401-6. (PMID: 26460044)
Psychol Med. 2010 Dec;40(12):1935-42. (PMID: 20624330)
Comput Psychiatr. 2024 Feb 07;8(1):1-22. (PMID: 38774429)
Neuropsychopharmacology. 2022 Jun;47(7):1339-1349. (PMID: 35017672)
Behav Neurosci. 2002 Apr;116(2):276-85. (PMID: 11998820)
Prog Neurobiol. 2010 Nov;92(3):345-69. (PMID: 20558235)
Nat Neurosci. 2024 Feb;27(2):309-318. (PMID: 38212586)
Lancet Psychiatry. 2015 Apr;2(4):305-13. (PMID: 26360083)
Elife. 2021 Mar 04;10:. (PMID: 33661094)
Ann N Y Acad Sci. 2010 Mar;1191:16-26. (PMID: 20392273)
Elife. 2019 Nov 26;8:. (PMID: 31769410)
Cogn Neuropsychiatry. 2017 Sep;22(5):373-390. (PMID: 28697644)
Psychol Med. 2019 May;49(7):1128-1137. (PMID: 29950184)
Lancet Psychiatry. 2014 Oct;1(5):399-402. (PMID: 26361002)
J Psychiatr Brain Sci. 2021;6(3):. (PMID: 34307899)
Nat Commun. 2021 Jul 30;12(1):4648. (PMID: 34330909)
J Neurosci. 2015 Jan 7;35(1):74-83. (PMID: 25568104)
Am J Psychiatry. 2016 Oct 1;173(10):980-988. (PMID: 27363508)
Nat Hum Behav. 2021 Sep;5(9):1190-1202. (PMID: 34316049)
Schizophr Bull. 2017 Mar 1;43(2):263-272. (PMID: 28177090)
Behav Brain Sci. 2009 Apr;32(2):183-98; discussion 198-246. (PMID: 19386174)
Acta Psychiatr Scand. 2019 Oct;140(4):360-370. (PMID: 31355420)
J Psychopharmacol. 2007 May;21(3):238-52. (PMID: 17591652)
Lancet Psychiatry. 2021 Aug;8(8):696-707. (PMID: 34246324)
Neuron. 2004 Dec 2;44(5):877-88. (PMID: 15572117)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Nov;7(11):1149-1157. (PMID: 35430406)
Cogn Sci. 2007 Mar 4;31(2):233-56. (PMID: 21635296)
Sci Rep. 2023 Jun 10;13(1):9485. (PMID: 37301915)
Nat Neurosci. 2013 Jul;16(7):966-73. (PMID: 23708143)
Biol Psychiatry. 2018 Nov 1;84(9):634-643. (PMID: 30007575)
JAMA Psychiatry. 2021 Mar 1;78(3):331-334. (PMID: 33206139)
Elife. 2020 May 26;9:. (PMID: 32452769)
PLoS Comput Biol. 2017 Aug 11;13(8):e1005684. (PMID: 28800597)
Cogn Neuropsychiatry. 2021 Jul;26(4):231-241. (PMID: 34102951)
Arch Gen Psychiatry. 2006 Jun;63(6):611-21. (PMID: 16754834)
J Pers Soc Psychol. 2010 Mar;98(3):434-49. (PMID: 20175623)
Sci Rep. 2023 Apr 13;13(1):6084. (PMID: 37055504)
Sci Rep. 2023 Mar 24;13(1):4841. (PMID: 36964175)
Br J Clin Psychol. 1999 Mar;38(1):83-96. (PMID: 10212739)
Science. 2008 Oct 3;322(5898):115-7. (PMID: 18832647)
Neuroimage Clin. 2020;26:102239. (PMID: 32182575)
Brain. 2007 Sep;130(Pt 9):2387-400. (PMID: 17690132)
Br J Psychiatry. 2014 Jan;204(1):20-9. (PMID: 24385461)
iScience. 2023 Aug 15;26(9):107643. (PMID: 37705957)
Neuroimage. 2014 Jan 1;84:971-85. (PMID: 24018303)
J Anxiety Disord. 2016 Apr;39:30-43. (PMID: 26945765)
Psychol Methods. 2020 Oct;25(5):653-672. (PMID: 32077709)
معلومات مُعتمدة: R21 MH110374 United States MH NIMH NIH HHS; Yale University Department of Psychiatry; R01MH112545 United States NH NIH HHS; Connecticut Mental Health Center (CMHC); Connecticut State Department of Mental Health and Addiction Services (DMHAS)
فهرسة مساهمة: Keywords: belief-updating; delusions; prediction error; predictive coding; psychosis; volatility
تواريخ الأحداث: Date Created: 20240418 Date Completed: 20240801 Latest Revision: 20240803
رمز التحديث: 20240803
مُعرف محوري في PubMed: PMC11292907
DOI: 10.1093/brain/awae122
PMID: 38637303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2156
DOI:10.1093/brain/awae122