دورية أكاديمية
Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia.
| العنوان: | Microneedle-Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia. |
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| المؤلفون: | Younis N; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Puigmal N; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02138, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA., Kurdi AE; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, 11-0236, Lebanon., Badaoui A; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Zhang D; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Morales-Garay C; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA., Saad A; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Cruz D; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA., Rahy NA; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Daccache A; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Huerta T; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA., Deban C; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Halawi A; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Choi J; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA., Dosta P; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02138, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA., Guo Lian C; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA., Artzi N; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02138, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA., Azzi JR; Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, 02115, USA. |
| المصدر: | Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (31), pp. e2312088. Date of Electronic Publication: 2024 Jun 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH Original Publication: Deerfield Beach, FL : VCH Publishers, 1989- |
| مواضيع طبية MeSH: | Hair Follicle* , T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/drug effects , Alopecia*, Animals ; Mice ; Humans ; Needles ; Immune Privilege ; Hydrogels/chemistry ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Interleukin-2/metabolism ; Immunomodulating Agents/chemistry ; Immunomodulating Agents/pharmacology |
| مستخلص: | Disorders in the regulatory arm of the adaptive immune system result in autoimmune-mediated diseases. While systemic immunosuppression is the prevailing approach to manage them, it fails to achieve long-lasting remission due to concomitant suppression of the regulatory arm and carries the risk of heightened susceptibility to infections and malignancies. Alopecia areata is a condition characterized by localized hair loss due to autoimmunity. The accessibility of the skin allows local rather than systemic intervention to avoid broad immunosuppression. It is hypothesized that the expansion of endogenous regulatory T cells (T (© 2024 Wiley‐VCH GmbH.) |
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| معلومات مُعتمدة: | Department of Medicine at Brigham and Women's Hospital for the Ignite Fund; Shark Tank Fund; 2022A001060 United States NH NIH HHS; 2022A001060 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: autoimmunity; drug delivery; immunoregulation microneedles; skin disorders |
| المشرفين على المادة: | 0 (Hydrogels) 0 (Immunologic Factors) 0 (Interleukin-2) 0 (Immunomodulating Agents) |
| تواريخ الأحداث: | Date Created: 20240419 Date Completed: 20240801 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1002/adma.202312088 |
| PMID: | 38638030 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1521-4095 |
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| DOI: | 10.1002/adma.202312088 |