دورية أكاديمية
Cutting edge of genetically modified pigs targeting complement activation for xenotransplantation.
العنوان: | Cutting edge of genetically modified pigs targeting complement activation for xenotransplantation. |
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المؤلفون: | Sun Q; Department of Endocrinology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Song SY; Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States., Ma J; School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China., Li D; Department of Pharmacy, Longquanyi District of Chengdu Maternity & Child Health Care Hospital, Chengdu, China., Wang Y; Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China., Yang Z; School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China., Wang Y; Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Center of Organ Transplantation, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. |
المصدر: | Frontiers in immunology [Front Immunol] 2024 Apr 04; Vol. 15, pp. 1383936. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | Graft Rejection*/prevention & control , Complement Activation*, Animals ; Humans ; Swine ; Transplantation, Heterologous ; Animals, Genetically Modified ; Retrospective Studies ; Complement System Proteins |
مستخلص: | In the quest to address the critical shortage of donor organs for transplantation, xenotransplantation stands out as a promising solution, offering a more abundant supply of donor organs. Yet, its widespread clinical adoption remains hindered by significant challenges, chief among them being immunological rejection. Central to this issue is the role of the complement system, an essential component of innate immunity that frequently triggers acute and chronic rejection through hyperacute immune responses. Such responses can rapidly lead to transplant embolism, compromising the function of the transplanted organ and ultimately causing graft failure. This review delves into three key areas of xenotransplantation research. It begins by examining the mechanisms through which xenotransplantation activates both the classical and alternative complement pathways. It then assesses the current landscape of xenotransplantation from donor pigs, with a particular emphasis on the innovative strides made in genetically engineering pigs to evade complement system activation. These modifications are critical in mitigating the discordance between pig endogenous retroviruses and human immune molecules. Additionally, the review discusses pharmacological interventions designed to support transplantation. By exploring the intricate relationship between the complement system and xenotransplantation, this retrospective analysis not only underscores the scientific and clinical importance of this field but also sheds light on the potential pathways to overcoming one of the major barriers to the success of xenografts. As such, the insights offered here hold significant promise for advancing xenotransplantation from a research concept to a viable clinical reality. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Sun, Song, Ma, Li, Wang, Yang and Wang.) |
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فهرسة مساهمة: | Keywords: C3a; C3b; complement systems; genetically modified pigs; xenotransplantation |
المشرفين على المادة: | 9007-36-7 (Complement System Proteins) |
تواريخ الأحداث: | Date Created: 20240419 Date Completed: 20240422 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC11024274 |
DOI: | 10.3389/fimmu.2024.1383936 |
PMID: | 38638432 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-3224 |
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DOI: | 10.3389/fimmu.2024.1383936 |