دورية أكاديمية
Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs.
| العنوان: | Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs. |
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| المؤلفون: | Bauer J; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Vlcek J; Department of Medicine I University Hospital, LMU Munich Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Pauly V; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Hesse N; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Xia R; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Mo L; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Chivukula AS; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Villgrater H; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Dressler M; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Hildebrand B; Department of Medicine I University Hospital, LMU Munich Munich Germany., Wolf E; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich Munich Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich Munich Germany., Rizas KD; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany., Bauer A; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; University Hospital for Internal Medicine III Medical University of Innsbruck Innsbruck Austria., Kääb S; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich Munich Germany., Tomsits P; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Schüttler D; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany., Clauss S; Department of Medicine I University Hospital, LMU Munich Munich Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance Munich Germany.; Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine University Hospital, LMU Munich Munich Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich Munich Germany. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 May 07; Vol. 13 (9), pp. e032405. Date of Electronic Publication: 2024 Apr 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Death, Sudden, Cardiac*/etiology , Myocardial Infarction*/physiopathology , Myocardial Infarction*/complications , Disease Models, Animal* , Electrocardiography* , Biomarkers*/blood, Animals ; Swine ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/etiology ; Ventricular Fibrillation/physiopathology ; Ventricular Fibrillation/etiology ; Risk Factors ; Male ; Ventricular Remodeling ; Heart Rate/physiology ; Action Potentials ; Sympathetic Nervous System/physiopathology ; Autonomic Nervous System/physiopathology |
| مستخلص: | Background: Periodic repolarization dynamics (PRD) is an electrocardiographic biomarker that captures repolarization instability in the low frequency spectrum and is believed to estimate the sympathetic effect on the ventricular myocardium. High PRD indicates an increased risk for postischemic sudden cardiac death (SCD). However, a direct link between PRD and proarrhythmogenic autonomic remodeling has not yet been shown. Methods and Results: We investigated autonomic remodeling in pigs with myocardial infarction (MI)-related ischemic heart failure induced by balloon occlusion of the left anterior descending artery (n=17) compared with pigs without MI (n=11). Thirty days after MI, pigs demonstrated enhanced sympathetic innervation in the infarct area, border zone, and remote left ventricle paralleled by altered expression of autonomic marker genes/proteins. PRD was enhanced 30 days after MI compared with baseline (pre-MI versus post-MI: 1.75±0.30 deg 2 versus 3.29±0.79 deg 2 , P <0.05) reflecting pronounced autonomic alterations on the level of the ventricular myocardium. Pigs with MI-related ventricular fibrillation and SCD had significantly higher pre-MI PRD than pigs without tachyarrhythmias, suggesting a potential role for PRD as a predictive biomarker for ischemia-related arrhythmias (no ventricular fibrillation versus ventricular fibrillation: 1.50±0.39 deg 2 versus 3.18±0.53 deg 2 [ P <0.05]; no SCD versus SCD: 1.67±0.32 deg 2 versus 3.91±0.63 deg 2 [ P <0.01]). Conclusions: We demonstrate that ischemic heart failure leads to significant proarrhythmogenic autonomic remodeling. The concomitant elevation of PRD levels in pigs with ischemic heart failure and pigs with MI-related ventricular fibrillation/SCD suggests PRD as a biomarker for autonomic remodeling and as a potential predictive biomarker for ventricular arrhythmias/survival in the context of MI. |
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| فهرسة مساهمة: | Keywords: autonomic remodeling; ischemic heart failure; periodic repolarization dynamics; pig model; sudden cardiac death |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240419 Date Completed: 20240507 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC11179938 |
| DOI: | 10.1161/JAHA.123.032405 |
| PMID: | 38639363 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
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| DOI: | 10.1161/JAHA.123.032405 |