Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy.

التفاصيل البيبلوغرافية
العنوان:	Morphological and clinical findings in placentas and newborns with a history of tobacco, alcohol, and other substance abuse during pregnancy.
المؤلفون:	Mendez-Reyes HF; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Franco-Olaya M; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Canon-Cubillos O; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Uribe-Lopez JM; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Delgado-Alvarez MC; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Velasquez-Portilla M; Medical School, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia., Olaya-C M; Pontificia Universidad Javeriana, Hospital Universitario San Ignacio, Bogotá, Colombia.
المصدر:	Journal of neonatal-perinatal medicine [J Neonatal Perinatal Med] 2024; Vol. 17 (2), pp. 217-224.
نوع المنشور:	Journal Article; Observational Study
اللغة:	English
بيانات الدورية:	Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101468335 Publication Model: Print Cited Medium: Internet ISSN: 1878-4429 (Electronic) Linking ISSN: 18784429 NLM ISO Abbreviation: J Neonatal Perinatal Med Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Amsterdam : IOS Press, 2008-
مواضيع طبية MeSH:	Placenta/pathology , Pregnancy Complications/epidemiology , Substance-Related Disorders/epidemiology , Substance-Related Disorders/complications, Humans ; Female ; Pregnancy ; Infant, Newborn ; Case-Control Studies ; Adult ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Smoking/adverse effects ; Smoking/epidemiology ; Risk Factors
مستخلص:	Background: Exposure to toxins during pregnancy is the main modifiable behavior that affects the placenta and, consequently, the fetus. In particular, smoking is a recognized risk factor for negative outcomes. Our study pretended to examine gross and microscopic placental features in women who reported exposure to tobacco, alcohol, or other psychoactive substances. Methods: In this observational case-control study, we collected 706 placentas to assess precise substance exposure histological-interaction features of in the placenta. We examined gross and microscopic placental features, and then recorded maternal and newborn clinical conditions. Results: We found that 4.8% of mothers admitted to consumption of some type of (harmful) substance. The most common pre-existing maternal condition was obesity (20.3%); predominant complications included amniotic infection (32.3%), urinary tract infection (14.5%) and hypertensive disorders of pregnancy (14.5%). In newborns, we discovered positive associations as respiratory distress syndrome. Macroscopically, exposed mothers had heavier placentas, more true knots, and single umbilical artery; microscopically, they were more likely to exhibit fetal vascular malperfusion (FVM). Conclusions: Until our present study, no research linked umbilical cord defects to toxic substance exposure; our study results do confirm association with adverse outcomes in neonates and alterations in the neuro-cardio-placental circuit through FVM. Implications: The results are confirming the importance of this modifiable risk factor and how its presence may potentially affect the course of pregnancy, as well as the health of both mother and child.
فهرسة مساهمة:	Keywords: Alcohol; cannabis; maternal smoking; opioids; placenta; umbilical cord
تواريخ الأحداث:	Date Created: 20240419 Date Completed: 20240517 Latest Revision: 20240717
رمز التحديث:	20240717
DOI:	10.3233/NPM-230104
PMID:	38640173
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1878-4429
DOI:	10.3233/NPM-230104