دورية أكاديمية
Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging.
| العنوان: | Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging. |
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| المؤلفون: | Shu P; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, P.R. China.; HBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen 518000, Guangdong, P.R. China.; University of Chinese Academy of Sciences, Beijing 100049, P.R. China., Mo J; The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, P.R. China., Li Z; The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, P.R. China., Li M; HBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co., Ltd., Shenzhen 518000, Guangdong, P.R. China., Zhu W; The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, P.R. China.; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou 510006, Guangdong, P.R. China., Du Z; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, Xinjiang, P.R. China.; University of Chinese Academy of Sciences, Beijing 100049, P.R. China. |
| المصدر: | Aging [Aging (Albany NY)] 2024 Apr 18; Vol. 16 (8), pp. 7153-7173. Date of Electronic Publication: 2024 Apr 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
| مواضيع طبية MeSH: | Skin Aging*/drug effects , Skin Aging*/radiation effects , Coumaric Acids*/pharmacology , Oxidative Stress*/drug effects , Oxidative Stress*/radiation effects , Ultraviolet Rays*/adverse effects , Vitamin A*/pharmacology , HaCaT Cells* , Drug Synergism*, Humans ; Keratinocytes/drug effects ; Keratinocytes/radiation effects ; Keratinocytes/metabolism ; Antioxidants/pharmacology |
| مستخلص: | Application of retinol (Vitamin A, VA) in skincare is limited for instability, poor water solubility, and skin intolerance that combats skin aging. We employed computer-aided virtual screening and cell experiments with transcriptomics, thereby unveiling the comprehensive gene expression and regulation pathway of photoaging HaCaT cell treated with ferulic acid (FA) in synergizing with VA. Through network pharmacology analysis, the combined use of VA and FA exhibited highly correlated cross-targets with skin aging acting on EGFR, PTPN1, ESR2, GSK3B, BACE1, PYGL, PTGS2 and APP. The indicators of oxidative stress, such as SOD, GSH, MDA, CAT and ROS in HaCaT cells after co-administration, were significantly improved from those in photoaging group ( p <0.0001). 155 differential expressed genes (DEGs) were specific between groups, while reducing the expression of PTGS2 was identified as an important regulatory factor in photoaging HaCaT cells by VA and FA. Those DEGs of co-administration group focused on oxidative-reduction enzyme activity, skin growth, keratinization, and steroid biosynthesis. Apparently, the co-administration of VA and FA effectively mitigated the process of UVB-induced photoaging by reducing oxidative stress injury, inflammation responses, and regulating cell growth. This synergistic approach significantly slowed down the photoaging progression and improved the applied performance of VA in HaCaT cells. |
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| فهرسة مساهمة: | Keywords: cooperative photoprotection; ferulic acid; oxidative stress; retinol; skin aging |
| المشرفين على المادة: | AVM951ZWST (ferulic acid) 0 (Coumaric Acids) 11103-57-4 (Vitamin A) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20240421 Date Completed: 20240506 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| مُعرف محوري في PubMed: | PMC11087097 |
| DOI: | 10.18632/aging.205749 |
| PMID: | 38643459 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-4589 |
|---|---|
| DOI: | 10.18632/aging.205749 |