دورية أكاديمية
أعرض في EDS

Diagnosing liposarcoma on (peri)-renal mass biopsy: A clinicopathological study of 30 cases.

التفاصيل البيبلوغرافية
العنوان: Diagnosing liposarcoma on (peri)-renal mass biopsy: A clinicopathological study of 30 cases.
المؤلفون: Potterveld SK; Department of Pathology, Stanford Medical Center, Stanford, CA, USA., Mubeen A; University of New Mexico, Albuquerque, NM, USA., Anderson WJ; Brigham and Women's Hospital, Boston, MA, USA., Clay MR; University of Colorado, Aurora, CO, USA., Bourgeau M; University of Colorado, Aurora, CO, USA., Charville GW; Department of Pathology, Stanford Medical Center, Stanford, CA, USA., Sangoi AR; Department of Pathology, Stanford Medical Center, Stanford, CA, USA.
المصدر: Histopathology [Histopathology] 2024 Aug; Vol. 85 (2), pp. 254-262. Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Blackwell Scientific Publications.
مواضيع طبية MeSH: Liposarcoma*/diagnosis , Liposarcoma*/pathology , Liposarcoma*/genetics , Kidney Neoplasms*/pathology , Kidney Neoplasms*/diagnosis , Kidney Neoplasms*/genetics , In Situ Hybridization, Fluorescence* , Immunohistochemistry* , Proto-Oncogene Proteins c-mdm2*/genetics , Proto-Oncogene Proteins c-mdm2*/metabolism, Humans ; Aged ; Female ; Male ; Middle Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Adult ; Biopsy ; Diagnosis, Differential ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/genetics
مستخلص: Aims: Classification of renal neoplasms on small tissue biopsies is in increasing demand, and maintaining broad differential diagnostic considerations in this setting is necessary. When evaluating a renal or perirenal tumour biopsy with sarcomatoid morphology, together with sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma as top diagnostic considerations, it is vital to additionally consider the possibility of well-differentiated and de-differentiated liposarcoma.
Methods and Results: This study reports a series of 30 biopsy samples from sites in or around the kidney collected from four institutions in which the correct diagnosis was either well-differentiated or de-differentiated liposarcoma. The majority (26 of 30, 87%) of lesions were accurately diagnosed on biopsy sampling, all of which incorporated testing for MDM2 by immunohistochemistry (IHC), fluorescence in-situ hybridisation (FISH) or a combination of the two as part of the diagnostic work-up. Tumour expression of MDM2 by IHC without confirmatory FISH analysis was sometimes (30%) sufficient to reach a diagnosis, but demonstration of MDM2 amplification by FISH was ascertained in the majority (57%) of biopsy samples. A diagnosis of de-differentiated liposarcoma was not definitively established until resection in four (13%) patients, as no MDM2 testing was performed on the corresponding pre-operative biopsies.
Conclusions: When a retroperitoneal tumour is not clinically suspected, histological consideration of a liposarcoma diagnosis may be overlooked. Implementation of ancillary immunohistochemical and cytogenetic testing can ultimately lead to a definitive diagnosis in this potentially misleading anatomical location.
(© 2024 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: MDM2; biopsy; kidney; liposarcoma; renal; retroperitoneum
المشرفين على المادة: EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
0 (Biomarkers, Tumor)
EC 2.3.2.27 (MDM2 protein, human)
تواريخ الأحداث: Date Created: 20240422 Date Completed: 20240714 Latest Revision: 20240714
رمز التحديث: 20240715
DOI: 10.1111/his.15197
PMID: 38646791
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2559
DOI:10.1111/his.15197