دورية أكاديمية
أعرض في EDS

Inhibition of 14-3-3 proteins increases the intrinsic excitability of mouse hippocampal CA1 pyramidal neurons.

التفاصيل البيبلوغرافية
العنوان: Inhibition of 14-3-3 proteins increases the intrinsic excitability of mouse hippocampal CA1 pyramidal neurons.
المؤلفون: Logue JB; Biomedical Sciences Department, College of Medicine, Florida State University, Tallahassee, Florida, USA., Vilmont V; Biomedical Sciences Department, College of Medicine, Florida State University, Tallahassee, Florida, USA., Zhang J; Biomedical Sciences Department, College of Medicine, Florida State University, Tallahassee, Florida, USA., Wu Y; Biomedical Sciences Department, College of Medicine, Florida State University, Tallahassee, Florida, USA., Zhou Y; Biomedical Sciences Department, College of Medicine, Florida State University, Tallahassee, Florida, USA.
المصدر: The European journal of neuroscience [Eur J Neurosci] 2024 Jun; Vol. 59 (12), pp. 3309-3321. Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-
مواضيع طبية MeSH: 14-3-3 Proteins*/metabolism , 14-3-3 Proteins*/genetics , Pyramidal Cells*/metabolism , Pyramidal Cells*/physiology , Pyramidal Cells*/drug effects , CA1 Region, Hippocampal*/metabolism , CA1 Region, Hippocampal*/physiology , Mice, Knockout* , Action Potentials*/physiology , Action Potentials*/drug effects, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Oligopeptides/pharmacology ; Proteins
مستخلص: 14-3-3 proteins are a family of regulatory proteins that are abundantly expressed in the brain and enriched at the synapse. Dysfunctions of these proteins have been linked to neurodevelopmental and neuropsychiatric disorders. Our group has previously shown that functional inhibition of these proteins by a peptide inhibitor, difopein, in the mouse brain causes behavioural alterations and synaptic plasticity impairment in the hippocampus. Recently, we found an increased cFOS expression in difopein-expressing dorsal CA1 pyramidal neurons, indicating enhanced neuronal activity by 14-3-3 inhibition in these cells. In this study, we used slice electrophysiology to determine the effects of 14-3-3 inhibition on the intrinsic excitability of CA1 pyramidal neurons from a transgenic 14-3-3 functional knockout (FKO) mouse line. Our data demonstrate an increase in intrinsic excitability associated with 14-3-3 inhibition, as well as reveal action potential firing pattern shifts after novelty-induced hyperlocomotion in the 14-3-3 FKO mice. These results provide novel information on the role 14-3-3 proteins play in regulating intrinsic and activity-dependent neuronal excitability in the hippocampus.
(© 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 1RO1MH115188-01 National Institutes of Health, USA
فهرسة مساهمة: Keywords: 14‐3‐3 proteins; electrophysiology; hippocampus; voltage‐gated calcium channels
المشرفين على المادة: 0 (14-3-3 Proteins)
0 (difopein)
0 (Oligopeptides)
0 (Proteins)
تواريخ الأحداث: Date Created: 20240422 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1111/ejn.16349
PMID: 38646841
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-9568
DOI:10.1111/ejn.16349