دورية أكاديمية
أعرض في EDS

Breakthrough Mpox Outbreak Investigation, the Delicate Balance Between Host Immune Response and Viral Immune Escape.

التفاصيل البيبلوغرافية
العنوان: Breakthrough Mpox Outbreak Investigation, the Delicate Balance Between Host Immune Response and Viral Immune Escape.
المؤلفون: Moretti M; From the Department of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel, Brussels., Meuwissen A; From the Department of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel, Brussels., Rezende AM, Zange S; Bundeswehr Institute of Microbiology, Munich, Germany., Van Nedervelde E; From the Department of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel, Brussels., de Block T; Clinical Virology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Vercauteren K; Clinical Virology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Demuyser T, Allard SD; From the Department of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), Universitair ziekenhuis Brussel, Brussels.
المصدر: Sexually transmitted diseases [Sex Transm Dis] 2024 Jul 01; Vol. 51 (7), pp. 499-503. Date of Electronic Publication: 2024 Apr 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: J B Lippincott Country of Publication: United States NLM ID: 7705941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-4521 (Electronic) Linking ISSN: 01485717 NLM ISO Abbreviation: Sex Transm Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia Pa : J B Lippincott
Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Disease Outbreaks* , Antibodies, Viral*/blood, Humans ; Male ; Adult ; Female ; Whole Genome Sequencing ; Vaccination ; Poxviridae Infections/epidemiology ; Poxviridae Infections/immunology ; Poxviridae Infections/virology ; Orthopoxvirus/immunology ; Orthopoxvirus/genetics ; Middle Aged
مستخلص: Background: Limited data are available on Mpox breakthrough infections.
Purpose: The purpose of this study is to investigate a Mpox breakthrough outbreak in 3 vaccinated individuals.
Methods: Study participants provided informed consent. Serology testing was performed in one involved individual (ID-1) using an in-house assay detecting anti-orthopoxvirus IgG. Whole genome sequencing (WGS) was carried out and compared with the reference sequence ON563414.3 ( https://www.ncbi.nlm.nih.gov/nuccore/ON563414.3/ ).
Results: Three individuals vaccinated with modified vaccinia Ankara-Bavaria Nordic contracted Mpox following one sexual intercourse event. One of them (ID-1) had received only one vaccine dose, while the other two were fully vaccinated. ID-1 presented to the sexual health clinic of the Universitair Ziekenhuis Brussel with proctitis related to Mpox. Despite one vaccination, serology testing Three months post vaccine showed absence of Mpox virus (MPXV) specific antibodies in ID-1. In contrast, 2 weeks after the sexual intercourse, seroconversion occurred. Whole genome sequencing of the isolated MPXV showed, compared with the reference sequence, a total of seven single nucleotide variants with four of them indicating protein amino-acid changes.
Conclusion: Incomplete MPXV vaccination as well as MPXV variants might result in breakthrough infections. Preventive measures, such as MPVX vaccination, could maintain immunity in individuals with higher risk of MPXV infection, and might lower disease severity.
(Copyright © 2024 American Sexually Transmitted Diseases Association. All rights reserved.)
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المشرفين على المادة: 0 (Antibodies, Viral)
تواريخ الأحداث: Date Created: 20240422 Date Completed: 20240617 Latest Revision: 20240618
رمز التحديث: 20240619
DOI: 10.1097/OLQ.0000000000001974
PMID: 38647249
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-4521
DOI:10.1097/OLQ.0000000000001974