دورية أكاديمية
Clinical associations with a polygenic predisposition to benign lower white blood cell counts.
العنوان: | Clinical associations with a polygenic predisposition to benign lower white blood cell counts. |
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المؤلفون: | Mosley JD; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. jonathan.d.mosley@vumc.org.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. jonathan.d.mosley@vumc.org., Shelley JP; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Dickson AL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Zanussi J; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Daniel LL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Zheng NS; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Yale School of Medicine, New Haven, CT, USA., Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Shi M; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Jarvik GP; Department of Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington Medical Center, Seattle, WA, USA., Khan A; Division of Nephrology, Dept of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Sherafati A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Kullo IJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Walunas TL; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Glessner J; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hakonarson H; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cox NJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Frangakis SG; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA., Vanderwerff B; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stein CM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Van Driest SL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Borinstein SC; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Shu XO; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Zawistowski M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Chung CP; Department of Medicine, University of Miami, Miami, FL, USA., Kawai VK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. |
المصدر: | Nature communications [Nat Commun] 2024 Apr 22; Vol. 15 (1), pp. 3384. Date of Electronic Publication: 2024 Apr 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide* , Multifactorial Inheritance* , Leukopenia*/genetics , Leukopenia*/blood, Humans ; Leukocyte Count ; Male ; Female ; Middle Aged ; Aged ; Adult ; Immunosuppressive Agents/therapeutic use |
مستخلص: | Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGS (© 2024. The Author(s).) |
التعليقات: | Update of: medRxiv. 2023 Aug 21;:. (PMID: 37662324) |
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معلومات مُعتمدة: | U01 HG006385 United States HG NHGRI NIH HHS; UL1 TR000445 United States TR NCATS NIH HHS; S10 RR025141 United States RR NCRR NIH HHS; U01 HG004424 United States HG NHGRI NIH HHS; U01 HG006389 United States HG NHGRI NIH HHS; U01 HG006828 United States HG NHGRI NIH HHS; U01 HG006380 United States HG NHGRI NIH HHS; RC2 GM092618 United States GM NIGMS NIH HHS; P50 GM115305 United States GM NIGMS NIH HHS; U01 HG006379 United States HG NHGRI NIH HHS; U01 HG011181 United States HG NHGRI NIH HHS; R35 GM131770 United States GM NIGMS NIH HHS; R01 GM130791 United States GM NIGMS NIH HHS; U01 HG006830 United States HG NHGRI NIH HHS; U01 HG006375 United States HG NHGRI NIH HHS; U01 HG004438 United States HG NHGRI NIH HHS; U01 HG006382 United States HG NHGRI NIH HHS; U19 HL065962 United States HL NHLBI NIH HHS; R01 GM126535 United States GM NIGMS NIH HHS; R01 HD074711 United States HD NICHD NIH HHS; U01 HG006388 United States HG NHGRI NIH HHS; U01 HG006378 United States HG NHGRI NIH HHS; UL1 RR024975 United States RR NCRR NIH HHS; R01 NS032830 United States NS NINDS NIH HHS; U01 HG004798 United States HG NHGRI NIH HHS; UL1 TR002243 United States TR NCATS NIH HHS |
المشرفين على المادة: | 0 (Immunosuppressive Agents) |
تواريخ الأحداث: | Date Created: 20240422 Date Completed: 20240424 Latest Revision: 20240506 |
رمز التحديث: | 20240506 |
مُعرف محوري في PubMed: | PMC11035609 |
DOI: | 10.1038/s41467-024-47804-5 |
PMID: | 38649760 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2041-1723 |
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DOI: | 10.1038/s41467-024-47804-5 |