دورية أكاديمية
أعرض في EDS

In vivo assessment of bladder cancer with diffuse reflectance and fluorescence spectroscopy: A comparative study.

التفاصيل البيبلوغرافية
العنوان: In vivo assessment of bladder cancer with diffuse reflectance and fluorescence spectroscopy: A comparative study.
المؤلفون: Zlobina NV; Department of Quantum Electronics, Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia.; Department of Fundamental Pathology, National Medical Research Center for Endocrinology, Moscow, Russia., Budylin GS; Biomedical Science and Technology Park, Laboratory of Clinical Biophotonics, First Moscow State Medical University, Moscow, Russia., Tseregorodtseva PS; Department of Quantum Electronics, Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.; Department of Fundamental Pathology, National Medical Research Center for Endocrinology, Moscow, Russia., Andreeva VA; NTO 'IRE-POLUS', Moscow, Russia., Sorokin NI; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Kamalov DM; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Strigunov AA; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Armaganov AG; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Kamalov AA; Department of Urology, Medical Research and Education Center, Lomonosov Moscow State University, Moscow, Russia., Shirshin EA; Department of Quantum Electronics, Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.
المصدر: Lasers in surgery and medicine [Lasers Surg Med] 2024 Jul; Vol. 56 (5), pp. 496-507. Date of Electronic Publication: 2024 Apr 22.
نوع المنشور: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8007168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9101 (Electronic) Linking ISSN: 01968092 NLM ISO Abbreviation: Lasers Surg Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York : Alan Liss
مواضيع طبية MeSH: Urinary Bladder Neoplasms*/diagnosis , Urinary Bladder Neoplasms*/pathology , Spectrum Analysis, Raman*/methods , Spectrometry, Fluorescence*/methods, Humans ; Female ; Male ; Aged ; Middle Aged ; Sensitivity and Specificity ; Cystoscopy ; Aged, 80 and over ; Spectroscopy, Near-Infrared/methods
مستخلص: Objectives: The aim of this work is to assess the performance of multimodal spectroscopic approach combined with single core optical fiber for detection of bladder cancer during surgery in vivo.
Methods: Multimodal approach combines diffuse reflectance spectroscopy (DRS), fluorescence spectroscopy in the visible (405 nm excitation) and near-infrared (NIR) (690 nm excitation) ranges, and high-wavenumber Raman spectroscopy. All four spectroscopic methods were combined in a single setup. For 21 patients with suspected bladder cancer or during control cystoscopy optical spectra of bladder cancer, healthy bladder wall tissue and/or scars were measured. Classification of cancerous and healthy bladder tissue was performed using machine learning methods.
Results: Statistically significant differences in relative total haemoglobin content, oxygenation, scattering, and visible fluorescence intensity were found between tumor and normal tissues. The combination of DRS and visible fluorescence spectroscopy allowed detecting cancerous tissue with sensitivity and specificity of 78% and 91%, respectively. The addition of features extracted from NIR fluorescence and Raman spectra did not improve the quality of classification.
Conclusions: This study demonstrates that multimodal spectroscopic approach allows increasing sensitivity and specificity of bladder cancer detection in vivo. The developed approach does not require special probes and can be used with single-core optical fibers applied for laser surgery.
(© 2024 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: autofluorescence; bladder cancer; diffuse reflectance spectroscopy; intraoperative diagnostics; laser spectroscopy
تواريخ الأحداث: Date Created: 20240423 Date Completed: 20240616 Latest Revision: 20240620
رمز التحديث: 20240620
DOI: 10.1002/lsm.23788
PMID: 38650443
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9101
DOI:10.1002/lsm.23788