دورية أكاديمية
The Effect of Halofuginone Use on Epidural Fibrosis After Spinal Surgery: An Animal Experiment.
| العنوان: | The Effect of Halofuginone Use on Epidural Fibrosis After Spinal Surgery: An Animal Experiment. |
|---|---|
| المؤلفون: | Yildiz MZ; Bahcesehir University, Pendik Medical Park Hospital, Department of Neurosurgery, Istanbul, Türkiye., Peker B, Unal TC, Dolas I, Gulsever CI, Dolen D, Sonmez E, Aras Y, Aydoseli A, Sabanci PA, Sencer A, Izgi AN |
| المصدر: | Turkish neurosurgery [Turk Neurosurg] 2024; Vol. 34 (3), pp. 435-440. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Turkish Neurosurgi[c]al Society Country of Publication: Turkey NLM ID: 9423821 Publication Model: Print Cited Medium: Internet ISSN: 2651-5032 (Electronic) Linking ISSN: 10195149 NLM ISO Abbreviation: Turk Neurosurg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ankara, Turkey : Turkish Neurosurgi[c]al Society, |
| مواضيع طبية MeSH: | Fibrosis*/drug therapy , Piperidines*/administration & dosage , Laminectomy*/adverse effects , Quinazolinones*/administration & dosage , Quinazolinones*/therapeutic use , Epidural Space*/pathology, Animals ; Rats ; Male ; Postoperative Complications/drug therapy ; Lumbar Vertebrae/surgery ; Disease Models, Animal ; Rats, Sprague-Dawley |
| مستخلص: | Aim: To investigate the effectiveness of local halofuginone application for spinal epidural fibrosis (EF) after lumbar laminectomy in rats. Material and Methods: Forty rats were equally divided into four groups (Groups I-IV; 10 rats in each group), and lumbar laminectomy was performed under general anesthesia. After laminectomy, Group I received saline (NaCl 0.9%) locally (control), Group II received spongostan, Group III received 0.5 mL of halofuginone-impregnated spongostan, and Group IV received 0.5 mL of halofuginone. Spongostan was used to prolong the exposure period of halofuginone. All rats were sacrificed after four weeks and evaluated according to histopathological criteria. A p-value of < 0.05 was considered statistically significant. Results: Fibrosis was significantly lower in Group IV than in Group I (p < 0.05). There was no significant difference in fibrosis between Group II/III and Group I. It was observed that spongostan increased fibrosis. Conclusion: Halofuginone helps prevent EF after spinal surgery. However, further clinical and experimental studies are needed to assess its safety in humans. |
| المشرفين على المادة: | L31MM1385E (halofuginone) 0 (Piperidines) 0 (Quinazolinones) |
| تواريخ الأحداث: | Date Created: 20240423 Date Completed: 20240514 Latest Revision: 20240707 |
| رمز التحديث: | 20240707 |
| DOI: | 10.5137/1019-5149.JTN.42998-22.3 |
| PMID: | 38650558 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2651-5032 |
|---|---|
| DOI: | 10.5137/1019-5149.JTN.42998-22.3 |