دورية أكاديمية

Amoebicidal effect of chlorine dioxide gas against pathogenic Naegleria fowleri and Acanthamoeba polyphaga.

التفاصيل البيبلوغرافية
العنوان: Amoebicidal effect of chlorine dioxide gas against pathogenic Naegleria fowleri and Acanthamoeba polyphaga.
المؤلفون: Sohn HJ; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea., Park AY; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea., Lee JH; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.; Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea., Yun KH; Department of Biomedical Science, Graduate School of Ajou University, Suwon, 16499, Republic of Korea., Song KJ; Chunsu Mountain Medicinal Herb Research Association, Bundanggu, 13637, Republic of Korea., Kim JH; Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, 52828, Republic of Korea. jkim@gnu.ac.kr., Shin HJ; Department of Microbiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea. hjshin@ajou.ac.kr.
المصدر: Parasitology research [Parasitol Res] 2024 Apr 23; Vol. 123 (4), pp. 192. Date of Electronic Publication: 2024 Apr 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Chlorine Compounds*/pharmacology , Naegleria fowleri*/drug effects , Acanthamoeba*/drug effects , Oxides*/pharmacology , Disinfectants*/pharmacology, Time Factors ; Survival Analysis ; Amebicides/pharmacology
مستخلص: The pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba polyphaga, are found in freshwater, soil, and unchlorinated or minimally chlorinated swimming pools. N. fowleri and A. polyphaga are becoming problematic as water leisure activities and drinking water are sources of infection. Chlorine dioxide (ClO 2 ) gas is a potent disinfectant that is relatively harmless to humans at the concentration used for disinfection. In this study, we examined the amoebicidal effects of ClO 2 gas on N. fowleri and A. polyphaga. These amoebae were exposed to ClO 2 gas from a ready-to-use product (0.36 ppmv/h) for 12, 24, 36, and 48 h. Microscopic examination showed that the viability of N. fowleri and A. polyphaga was effectively inhibited by treatment with ClO 2 gas in a time-dependent manner. The growth of N. fowleri and A. polyphaga exposed to ClO 2 gas for 36 h was completely inhibited. In both cases, the mRNA levels of their respective actin genes were significantly reduced following treatment with ClO 2 gas. ClO 2 gas has an amoebicidal effect on N. fowleri and A. polyphaga. Therefore, ClO 2 gas has been proposed as an effective agent for the prevention and control of pathogenic free-living amoeba contamination.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: NRF-2021R1C1C2009518 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT); NRF-2021R1C1C2009518 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT); NRF-2021R1C1C2009518 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT); NRF-2021R1C1C2009518 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT); NRF-2021R1C1C2009518 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)
فهرسة مساهمة: Keywords: Acanthamoeba polyphaga; Naegleria fowleri; Amoebicidal effect; Chlorine dioxide (ClO2) gas; Disinfectant
المشرفين على المادة: 8061YMS4RM (chlorine dioxide)
0 (Chlorine Compounds)
0 (Oxides)
0 (Disinfectants)
0 (Amebicides)
تواريخ الأحداث: Date Created: 20240423 Date Completed: 20240423 Latest Revision: 20240510
رمز التحديث: 20240510
DOI: 10.1007/s00436-024-08215-z
PMID: 38652173
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1955
DOI:10.1007/s00436-024-08215-z