دورية أكاديمية
Threonine dehydrogenase regulates neutrophil homeostasis but not H3K4me3 levels in zebrafish.
| العنوان: | Threonine dehydrogenase regulates neutrophil homeostasis but not H3K4me3 levels in zebrafish. |
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| المؤلفون: | Li NZ; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Wang ZX; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Zhang F; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Feng CZ; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China.; Department of Clinical Laboratory, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Jiangsu, China., Chen Y; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Liu DJ; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Chen SB; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Jin Y; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Zhang YL; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Xie YY; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Huang QH; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China., Wang L; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China., Li B; Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China., Sun XJ; Shanghai Institute of Hematology, State Key Laboratory of Omics and Diseases, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, China. |
| المصدر: | The FEBS journal [FEBS J] 2024 Aug; Vol. 291 (15), pp. 3367-3383. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, c2005- |
| مواضيع طبية MeSH: | Zebrafish*/genetics , Zebrafish*/metabolism , Neutrophils*/metabolism , Histones*/metabolism , Histones*/genetics , Homeostasis*, Animals ; Alcohol Oxidoreductases/metabolism ; Alcohol Oxidoreductases/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Hematopoiesis/genetics ; Mice |
| مستخلص: | l-threonine dehydrogenase (Tdh) is an enzyme that links threonine metabolism to epigenetic modifications and mitochondria biogenesis. In vitro studies show that it is critical for the regulation of trimethylation of histone H3 lysine 4 (H3K4me3) levels and cell fate determination of mouse embryonic stem cells (mESCs). However, whether Tdh regulates a developmental process in vivo and, if it does, whether it also primarily regulates H3K4me3 levels in this process as it does in mESCs, remains elusive. Here, we revealed that, in zebrafish hematopoiesis, tdh is preferentially expressed in neutrophils. Knockout of tdh causes a decrease in neutrophil number and slightly suppresses their acute injury-induced migration, but, unlike the mESCs, the level of H3K4me3 is not evidently reduced in neutrophils sorted from the kidney marrow of adult tdh-null zebrafish. These phenotypes are dependent on the enzymatic activity of Tdh. Importantly, a soluble supplement of nutrients that are able to fuel the acetyl-CoA pool, such as pyruvate, glucose and branched-chain amino acids, is sufficient to rescue the reduction in neutrophils caused by tdh deletion. In summary, our study presents evidence for the functional requirement of Tdh-mediated threonine metabolism in a developmental process in vivo. It also provides an animal model for investigating the nutritional regulation of myelopoiesis and immune response, as well as a useful tool for high-throughput drug/nutrition screening. (© 2024 Federation of European Biochemical Societies.) |
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| معلومات مُعتمدة: | Samuel Waxman Cancer Research Foundation; 32030019 National Natural Science Foundation of China; 82200116 National Natural Science Foundation of China; 31872817 National Natural Science Foundation of China; Innovative Research Team of High-level Local Universities in Shanghai; 2019CXJQ01 Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research; 20152506 Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant; 22YF1425300 Shanghai Sailing Program; 2018YFA0107802 National Key Research and Development Plan of China; 2021YFA1300100 National Key Research and Development Plan of China; 2018YFC1004500 National Key Research and Development Plan of China |
| فهرسة مساهمة: | Keywords: neutrophil; threonine dehydrogenase; threonine metabolism; trimethylation of histone H3 lysine 4; zebrafish |
| المشرفين على المادة: | 0 (Histones) EC 1.1.1.103 (L-threonine 3-dehydrogenase) EC 1.1.- (Alcohol Oxidoreductases) 0 (histone H3 trimethyl Lys4) 0 (Zebrafish Proteins) |
| تواريخ الأحداث: | Date Created: 20240423 Date Completed: 20240802 Latest Revision: 20240802 |
| رمز التحديث: | 20240802 |
| DOI: | 10.1111/febs.17138 |
| PMID: | 38652546 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1742-4658 |
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| DOI: | 10.1111/febs.17138 |